020–1.095) Palbociclib solubility dmso seem to be the independent risk factors
for anemia in CD. Conclusion: Patient with CD has high morbidity of anemia, and microcytic anemia is the most common type. Weight and ESR seems to be the independent facorts to anemia. Key Word(s): 1. Crohn’s disease; 2. anemia; 3. retrospective study; Presenting Author: MIN WANG Additional Authors: HONGGANG WANG, FAMING ZHANG Corresponding Author: FAMING ZHANG Affiliations: Nanjing Medical University Objective: Treatment of refractory ulcerative colitis has high recurrences with failure to respond to conventional medication therapy, which prompted the need for alternative therapies. One such therapy is fecal microbiota transplantation (FMT). Intestinal microbiota has important roles in the post-natal structural and functional maturation of the gut. FMT has shown some usefulness in the treatment of UC, but no prospective data exists on see more the efficacy of FMT through mid-gut in patients with refractory ulcerative colitis. This was a prospective study to explore the efficacy of FMT through mid-gut in treatment of refractory ulcerative colitis. Methods: The included criteria for refractory CD and the excluded criteria were based on our study protocol shown in Clinicaltrial. gov (NCT01790061). We reviewed records from 10 patients, 20 to 64 years of age, with refractory Ulcerative colitis, who had undergone FMT. FMT was performed through mid-gut by infusing fresh donor feces into horizontal part of duodenum.
Before transplantation, the patients had fasted for about 8 hours. Data on tolerability, adverse events were collected during FMT and weekly for first two weeks and monthly for first three months after FMT.
Results: No serious adverse events were 上海皓元 noted. Mild to moderate (diarrhea) adverse events were observed and self-limiting. During the first week after fecal transplantation, symptoms (abdominal pain score, diarrhea and frequency, mucous stool, pus and blood stool et al.) resolved in most. Of 10 patients, abdominal pain resolved in 40% and improved in 60% of patients within an average of one week after FMT; diarrhea resolved in 60% and improved in 30% of patients within an average of one week after FMT; mucous stool resolved in 40% and improved in 50% of patients within an average of one week after FMT.; pus and blood stool, resolved in 60% and improved in 40% of patients within an average of one week after FMT. Three of our patients have skin problem before FMT, which got marked improvement after FMT. Meantime, one of our patient has Diabetes Mellitus history about 10 years who is using insulin to control her blood sugar. We found her blood sugar also got marked improvement using fewer insulin after FMT. No immediate complications of fecal transplantation were observed. Conclusion: FMT through mid-gut is an effective, durable, safe, and acceptable treatment for refractory ulcerative colitis and it can be the rescue therapy for refractory ulcerative colitis. Key Word(s): 1. FMT; 2.