Cal center staff and the study of the chairman. Statistical Dorzolamide Trusopt analyzes were performed by CALGB statisticians. The program for quality Assurance of the CALGB, members of the Audit Committee visit all participating institutions reviewed at least once every three years to source documents. The auditors verify compliance with applicable provisions of confinement and protocol requirements Lich those on the west Hlbarkeit, treatment, side effects, tumor response, and results in a sample of protocols at each establishment. Such a revision to the place of medical records was conducted for 49 of the 101 patients included in the study. RESULTS Patients A total of 101 patients in this study were enrolled from October 1998 to July 2001. A patient was classified as non hig f Rderf, And one patient never started treatment protocol. The long term results are based on 99 patients. Patient data and Vismodegib 879085-55-9 clinical data are summarized in Table 1. The enrollment data show a typical group of patients who have increased Hten developed PSA after local treatment for this time.
Sixty six percent of patients were responsible for the initial Pazopanib Armala treatment consisting of a radical prostatectomy, received w While 71% had back U prior radiotherapy, usually as a secondary Re or salvage therapy. Median PSA at the time of enrollment was 3.8. These patients were largely asymptomatic, with only 10% take a pain reliever for some reason. Their performance status is high, with 76% as ECOG 0, and laboratory parameters such as H Hemoglobin and alkaline phosphatase reflects their low systemic tumor burden. Gleason score was evaluated at the local level, had 78% of patients had a Gleason score of 7 Rderkriterien for F, No patient had evidence of metastases or grossly apparent locally recurrent or persistent disease. Clinical Results Almost all patients met the predefined criteria for a PSA response, with a lower PSA level of 80% observedin 96 of 99 patients. The other 3 patients had Feedb Length of 77%, 73% and 38%, which was not CONFIRMS best. Sixty percent of enrolled patients achieved an undetectable PSA. over 50% of patients had a PSA decline of 1 ng / ml after the first month, and the median time to nadir value was 3.2 months. The median progression free survival of free PSA was 85 months and 5 years of PSA progression axitinib survival rate was 65% without. With 10 years of follow up, the median survival time not reached, and the rate of overall survival at 5 years was 87%.
The prostate cancer five years survival rate was 95.7% specific. The rate metastasisfree 5 years was 97.5%. An exploratory analysis on the Gleason score was performed based. The median time to PSA progression or death in patients with Gleason sum basis from August to October was 67 months compared to 104 months for patients with Gleason 8. Patient disposition for the patients is summarized in Figure 2. From 99 eligible patients, 22 remain on therapy. Of the 77 patients from the treatment protocol, 43 patients died. Of these, 13 were Todesf Ll due to progressive prostate cancer. Other causes of death included 5 patients with cardiac events or events that were potentially cardiac nature may need during the treatment protocol had. To go Gardens two patients with congestive heart failure and / or Isch Chemistry, 1 with a heart.
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