2007, H. Pexidartinib clinical trial Voglmayr & W. Jaklitsch, W.J. 3158 (WU 29479, culture C.P.K. 3150). Norfolk, Thetford, Emilys Wood, near Brandon, MTB 35-31/2, 52° 28′ 08″ N, 00° 38′ 20″ E, elev. 20 m, on partly decorticated branch of Fagus sylvatica 3.5 cm thick on the ground, present as anamorph, soc. Hypocrea neorufoides, 13 Sep. 2004, H. Voglmayr & W. Jaklitsch (deposited as H. neorufoides WU 29300; culture C.P.K. 1978). Thetford, close to the town on the right side of the road from Elveden, at a parking place, 52° 24′ 00″ N, 00° 42′ 43″ E, elev. 30 m, on branches of Fagus sylvatica 10 cm thick in a small pile on the ground, holomorph, teleomorph immature, culture from conidia, 12 Selleck CH5183284 Sep. 2004, H. Voglmayr & W. Jaklitsch,

W.J. selleck kinase inhibitor 2704 (WU 29477, culture C.P.K. 1977). Notes: Hypocrea stilbohypoxyli is a typical species of the section Trichoderma with low tendency to form pulvinate stromata, i.e. often maturing when effused. It produces the largest stromata of the section in Europe apart from H. ochroleuca and H. subeffusa. The anamorph

of H. stilbohypoxyli may attract attention in nature due to its abundance under favourable conditions and its bright blue-green colour. In culture, T. stilbohypoxyli is conspicuous particularly on CMD at 25°C, due to pustules with a yellow reverse that consist of a dense core of curved conidiophores and phialides reminiscent of H. rufa/T. viride, surrounded by regularly tree-like conidiophores. Characteristic are also the irregularly thickened cells in surface hyphae around pustules, and notable the abundant chlamydospores on SNA at 30°C that are sometimes reminiscent of ascospores. These cultural traits have not been ascertained in non-European strains.

According to Samuels et al. (2006a) H. stilbohypoxyli has a remarkably wide geographic Nintedanib (BIBF 1120) distribution. Whether or not all these specimens and cultures represent a single species is not clear. In fact, although clustering together, the European isolates differ from others consistently in gene sequences, one nucleotide in ITS, five in rpb2 and 21 nucleotides in tef1 introns four and five. Other differences deduced from the description in Samuels et al. (2006a) are smaller stroma size, slightly smaller ascospores, faster growth, distinctly zonate, green colonies on PDA, and infrequent chlamydospores in non-European strains. Hypocrea subeffusa Jaklitsch, sp. nov. Fig. 22 Fig. 22 Teleomorph of Hypocrea subeffusa. a–i. Dry stromata (a. habit, nearly fresh; b. stroma initial; c–e. immature). j. Rehydrated mature stroma. k. Stroma of j in 3% KOH. l. Hairs on stroma surface. m. Perithecium in section. n. Rehydrated stroma surface. o. Stroma surface in face view. p. Cortical and subcortical tissue in section. q. Subperithecial tissue in section. r. Stroma base in section. s–u. Asci with ascospores (t, u. in cotton blue/lactic acid). a, c, e, j–t. holotype WU 29487. b, d, g–i. WU 29488.