Contrasts were assessed BGJ398 nmr according to suppression of neural activity (activation of related trials < activation of unrelated trials) and to enhancement of neural activity (activation of related trials > activation of unrelated trials). We showed associative suppression effects in bilateral STG, anterior cingulate cortex (ACC), in occipito-temporal brain areas such as the lingual and the parahiccocampal

gyrus and in medial frontal brain areas (BA 6/BA 9). All brain regions showing neural associative Inhibitors,research,lifescience,medical priming effects are presented in Table ​Table4.4. Brain areas belonging to a priori ROIs; that is, brain regions usually involved during semantic processing as highlighted in the Introduction section (i.e., inferior and middle frontal regions, inferior parietal, middle, superior, and inferior temporal regions including the fusiform Inhibitors,research,lifescience,medical gyrus in both hemispheres) are marked in bold face. Brain areas showing neural associative suppression effects are shown in Figure ​Figure2.2.

Additionally, we present the mean contrast estimates for related compared to unrelated trials for the neural associative priming effects in the left and right STG. No associative enhancement effects were observed. A comparison of related and unrelated trials with the neutral condition was carried out to exclude that our data Inhibitors,research,lifescience,medical were affected by inhibition effects. Consistent with the behavioral data of Experiment 1, no inhibition effects (unrelated > neutral) were observed in relevant brain areas for semantic processing (Table S1). Table 4 Brain areas showing (A) neural associative suppression effects for both linguistic tasks, (B) linguistic task effects, and (C) Relatedness × Linguistic task interactions Figure Inhibitors,research,lifescience,medical Inhibitors,research,lifescience,medical 2 Brain areas showing neural associative suppression, that is significantly lower activation for related than for unrelated trials in native speakers of German (n = 36), independently of the linguistic task (P < 0.001 uncorrected).

Mean contrast … Linguistic task effects No linguistic task effects could be observed in prefrontal brain areas. ROI analyses in the LIFG (a) active during semantic processing in a meta-analysis (http://www.neurosynth.org; MNI coordinates: very x = −44, y = 24, z = 4), and (b) showing a linguistic task effect in the Wright et al. (2011) study (MNI coordinates: −36, 33, −12) did not reveal task-specific activation, even at liberal significance thresholds of P < 0.005 (uncorrected). Consistently, no brain region was more active for semantic categorization compared to silently thinking about a word’s meaning at the specified threshold of P < 0.001 (uncorrected) in the full-factorial ANOVA. In contrast, higher activation was observed in occipital and inferior parietal brain areas for silently thinking compared to semantic categorization (see Table ​Table55 section B) at P < 0.001 (uncorrected).