Initially, the diverticulum would lie superior to the pancreas. With further extension, the diverticulum could project posterior to the pancreas. Acquired gastric diverticula in contrast are pseudodiverticula, less common and typically located in the antrum.

They usually present with a background history of other gastrointestinal pathology, such as peptic ulcer disease, malignancy, pancreatitis, or gastric outlet obstruction. Gastric diverticula had been reported following surgical procedures on the stomach, including Roux-en-Y gastric bypass [4, 10, 11]. Investigations Accurate GSK872 in vitro diagnosis is essential given the risk for severe complications, including bleeding and perforation, as well as the association with ectopic mucosa and potential LY2874455 molecular weight for malignant transformation [12]. The condition can be diagnosed by radiological or endoscopic examinations. This is usually accomplished with upper gastrointestinal contrast radiographic study (UGI) or oesophagogastrodudenoscopy

(OGD). These are the most reliable diagnostic tests but reports in the literature confirm that they can give false negative results [13, 14]; especially for a diverticulum with a narrow neck that GDC-0941 mouse precludes entry of the contrast or scope. It is stated that the GD is best identified during UGI study using a right, anterior oblique view with the patient in a supine, slightly left lateral decubitus and Trendelenburg position [13–16]. In a large review, Palmer [13] reported that 14 of 262 (5%) GDs are missed during UGI study. Other reports support the use of OGD [10, 17] for diagnosis. Distension of the diverticulum by the scope may mimic the patient’s symptoms and this maneuver may indicate

which patients would benefit from resection [10]. Other reports suggest that computer tomography scanning may be effective; however, the accuracy of this imaging modality is not widely accepted because of the possible misdiagnosis [18, 19]. Management There is no specific treatment plan for an asymptomatic diverticulum [9, 20]. The appropriate management for a symptomatic GD depends mainly on the severity Inositol oxygenase of the presenting complaints. Medical and non surgical therapy Protein pump inhibitors therapy for few weeks is reported to resolve the symptoms in proven cases of GD [9]. However it is important to note that this does not resolve the underlying pathology and some studies report that patients presented again with refractory symptoms of dyspepsia and worsening epigastric pain that did not settle with either protein pump inhibitors or histamine receptor blockers [21]. There are also reports in the literature of successful endoscopic management of cases of gastric diverticulum that presented with active upper GI bleed. None of these studies reported any further complications that warranted further surgical management [22, 23].