References 1. Olczak T, Simpson W, Liu X, Genco CA: Iron and heme utilization in Porphyromonas gingivalis . FEMS Microbiol Rev 2005, 29:119–144.PubMedCrossRef 2. Lewis JP, Plata K, Yu F, Rosato A, Anaya C: Transcriptional organization, regulation and role of the Porphyromonas gingivalis W83 hmu haemin uptake locus. Microbiology 2006, 152:3367–3382.PubMedCrossRef 3. Olczak T, Sroka A, Potempa J, Olczak M: Porphyromonas gingivalis HmuY

and HmuR – further characterization of a novel mechanism of heme utilization. Arch Microbiol 2008, 183:197–210.CrossRef 4. Wojtowicz H, Guevara T, Tallant C, et al.: Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis IPI-549 price . PLoS Pathog 2009, 5:e1000419.PubMedCrossRef 5. Olczak MK-1775 concentration T, Wojtowicz H, Ciuraszkiewicz J, Olczak MR:

Species specificity, surface exposure, protein expression, immunogenicity, and participation in biofilm formation of Porphyromonas gingivalis HmuY. BMC Microbiol 2010, 10:134.PubMedCrossRef 6. Trindade SC, Olczak T, Gomes-Filho IS, et al.: Induction of interleukin (IL)-1β, IL-10, IL-8 and immunoglobulin G by Porphyromonas gingivalis HmuY in humans. J Periodontal Res 2012, 1:27–32.CrossRef 7. McGhee ML, Ogawa T, Pitts AM, et al.: Cellular analysis of functional mononuclear cells from chronically inflammed gingival tissue. Reg Immunol 1989, 2:103–110.PubMed 8. Nakajima T, Ueki-Maruyama K, Oda T, et al.: Regulatory T-cells infiltrate periodontal disease tissues. J Dent Res 2005, 84:639–643.PubMedCrossRef 9. Cardoso CR, Garlet GP, Moreira AP, Martins-Junior W, Rossi MA, Silva JS: Characterization of CD4 + CD25 + natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J Leukoc Biol 2008, 84:311–318.PubMedCrossRef 10. Ohyama H, Kato-kogoe N, Kuhara A, et al.: The involvement of IL-23 and the Th17 pathway in periodontitis. J Dent Res 2009, 88:633–638.PubMedCrossRef 11. Schenkein HA, Koertge TE, Brooks CN, Sabatini R, Topoisomerase inhibitor Purkall DE, Tew JG: IL-17 in sera from

patients with aggressive periodontitis. J Dent Res 2010, 89:943–947.PubMedCrossRef 12. Ohlrich EJ, Cullinan MP, Seymour GJ: The immunopathogenesis Mannose-binding protein-associated serine protease of periodontal disease. Aust Dent J 2009, 54:2–10.CrossRef 13. Tauban MA, Kawai T: Involvement of T-lymphocytes in periodotal disease and in direct and indirect induction of bone resorption. Crit Rev Biol Med 2001, 12:125–135.CrossRef 14. Tonetti MS, Cortellini D, Lang NP: In situ detection of apoptosis at sites of chronic bacterially induced inflammation in human gingiva. Infect Immun 1998, 66:5190–5195.PubMed 15. Ju ST, Panka DJ, Cui HER, et al.: Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 1995, 373:444–448.PubMedCrossRef 16.