Statistically significant fall in blood pressure (BP) was 19 and 21 mm Hg for test doses of 30 and 100 mg/kg, respectively (p <= 0.05). Our current work confirms the folkloric uses

of F. tenacissima as spasmogenic, antispasmodic (in large doses) and antihypertensive drug.”
“Many RG-7112 clinical trial patients with Type 2 diabetes mellitus are characterized by a typical dyslipidemia. This dyslipidemia includes hypertriglyceridemia, low HDL-C and mildly elevated LDL-C with a predominance of small dense LDL particles. The mechanisms leading to hypertriglyceridemia directly relate to insulin resistance and hyperglycemia. Both factors result in overproduction of triglyceride-rich lipoproteins from the liver, decreased clearance of triglyceride-rich lipoproteins and, in some cases, an altered postprandial lipoprotein metabolism. The origin of low HDL-C and the predominance of small dense LDL is closely linked to hypertriglyceridemia. Although each of these abnormalities is probably related to atherosclerosis, it is unclear whether only one component and if so which one mediates most of the risk or whether the combination of lipid abnormalities is responsible for the excessive cardiovascular risk. Despite these uncertainties, current treatment recommendations focus on achieving a certain LDL-C goal. Therapeutic strategies include lifestyle changes, glucose control and specific lipid-lowering therapy. In most patients

statin therapy should be the first choice, if a lipid lowering drug is indicated, as outcome data have proven their effectiveness in diabetic subjects. In patients with eFT-508 clinical trial severe isolated hypertriglyceridemia fibrates may be used. In patients at very high risk, combination therapy to further lower LDL-C or to address LDL-C, HDL-C and triglycerides should be considered.”
“Sabo Wuse, a resettlement in Tafa Local Government Area of Niger State inhabits the original inhabitants of Wuse Ruboxistaurin in Abuja, the Federal Capital of Nigeria. Despite the close proximity of about 65km

to the urban settlement of Abuja, Sabo Wuse is still a relatively remote settlement; their lifestyle remained more or less unchanged and therefore, relied on their traditional knowledge for health care delivery. Recent ethnobotanical survey in Sabo Wuse has documented plants not indigenous to the area. In view of this, a survey was carried out to identify and document plants and animal materials sold by the Yan-shimfidas in the local settlement and to study their uses in treatment of ailments and other socio-cultural problems. The result shows that most of the herb sellers of Sabo Wuse were immigrants from the northern part of the country who had stayed in the village of Sabo Wuse for over twenty years. Thirty-four different plant species in twenty-one different families were documented. These were in the form of stem barks, leaves, roots, fruits, seeds, flower buds and fruit juices.