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“OBJECTIVE: Infection and inflammation play a role in carcinogenesis, and highly prevalent oral and dental diseases have been significantly linked to some types

of cancer. This article reviews current literature in this area.

MATERIALS AND METHODS: AZD7762 supplier Open literature review using the PubMed database and focused on publications from 2000 to 2010.

RESULTS: Numerous potential mechanisms are implicated in the oral disease/carcinogenesis paradigm, including infection-and inflammation-associated cell pathology and microbial carcinogen metabolism. Poor oral hygiene is associated with oral cancer, but there is also evidence of a possible link between oral or dental infections and malignancies in general.

CONCLUSION: Oral infections may trigger malignant transformation in tissues of the mouth and other organs. However, scientific evidence to date remains weak and further well-conducted studies are warranted before cancer can be properly added to the list of oral infection-related systemic diseases. Oral Diseases (2011) 17, 779-784″
“Weight loss issues are one of the problems that can affect patients after undergoing bariatric surgery. We report the

feasibility, safety and preliminary outcomes of laparoscopic conversion of Roux-en-Y gastric bypass (RYGB) to sleeve gastrectomy (SG), as a first step of duodenal switch (DS), for insufficient weight loss or weight regain.

Between August 2007 and November 2009, four patients benefited from laparoscopic conversion for insufficient weight loss or weight regain, mainly due Vactosertib to a new dietary behaviour such as sweet eating. At the time of RYGB, the mean weight and body mass index (BMI) was 118.5 +/- 32.8 kg and

43.2 +/- 8 kg/m(2), respectively. The mean interval time between RYGB and conversion to SG was 36.7 +/- 15.6 months. At the time of conversion, the mean weight, BMI, % excess weight loss (%EWL) and % excess BMI loss (%EBMIL) was 101.7 +/- 24.7 kg, 37.3 +/- 6.6 kg/m(2), 27.5 +/- 11.8% and 26.5 +/- 12%, respectively. The procedure involved the dismantling of both anastomosis, performance of SG before restoration of gastric continuity, and new small check details bowel anastomosis.

Mean operative time was 233.7 +/- 46.4 min. There were no conversions to open surgery and no mortality. One patient developed a gastric fistula. Mean hospital stay was 20.2 +/- 17.9 days. After a mean follow-up of 11 +/- 12.8 months, the mean weight, BMI, %EWL and %EBMIL was 81 +/- 12.1 kg, 30.3 +/- 5.1 kg/m(2), 59.3 +/- 31.5% and 42.3 +/- 34.5%, respectively. During follow-up, one patient underwent the second step of DS.

Laparoscopic conversion of RYGB to SG is feasible and safe despite the development of gastric fistula. Weight loss is increased, leaving the patients in better conditions to undergo the second step of DS.