10 These studies had a maximum follow-up of 7.3 years. The fatty liver index (FLI) is a surrogate marker of a fatty liver. It was validated in a large group of subjects with or without suspected liver disease11 and was associated with coronary heart disease and early atherosclerosis in a cross-sectional study.12 The aim of this study was to assess the relationship between FLI and hepatic-related, all-cause, CVD, and cancer mortality rates in the Cremona study, a 1990-1991 population survey designed to establish the prevalence of selleck products diabetes in Lombardy, Italy.13, 14 In this
cohort, the vital status and the time of death were ascertained through Regional Health Registry files, and the causes of death were classified with the International Classification of Diseases. The follow-up was 15 years, which is the shortest time needed to explore the effects of metabolic risk factors (diabetes status, insulin resistance, body fatness, and metabolic syndrome) on mortality.15, 16 BMI, body mass index; CI, confidence
interval; CVD, cardiovascular disease; FLI, fatty liver index; GGT, γ-glutamyltransferase; HOMA-IR, homeostasis model assessment of insulin resistance; HR, hazard ratio; IGT, impaired glucose tolerance; NAFLD, nonalcoholic fatty liver disease; OGTT, oral glucose tolerance test. The Cremona study was a large population survey in the health district of Cremona (38,643 inhabitants from three www.selleckchem.com/small-molecule-compound-libraries.html representative municipalities: Cremona, Casalbuttano, and Vescovato) that was performed (1) to estimate the prevalence of diagnosed and undiagnosed diabetes and impaired glucose tolerance (IGT) according to the oral glucose tolerance test (OGTT) and the World Health Organization criteria in Northern Italy and (2) to set up a population cohort in anticipation of a follow-up study.13, 14 After an information campaign, 2074 randomly selected subjects who were more than 40 years old visited one of the three clinics set up for this program (one in each town), and data
for 2011 of these subjects were available for this analysis. The anthropometric and laboratory features are MTMR9 summarized in Table 1. The subjects’ medical histories, anthropometric parameters, and clinical data were collected according to a standard protocol by trained interviewers. Venous blood samples were collected after 12 hours of overnight fasting and 2 hours after the oral administration of 75 g of glucose monohydrate. Further details about the study protocol have been reported previously.13, 14 Fifteen years later, the vital status and the time of death were ascertained through Regional Health Registry files, and the causes of death were classified with the International Classification of Diseases, Ninth Revision (death codes 401-448 for CVD, death codes 140.0-208.9 for cancer, death codes 155-156 for hepatic diseases related to hepatocarcinoma, and death codes 571-573 for hepatic diseases related to cirrhosis).