001, P<0.001). The frequency of H+/P+/C combined genotype was significantly higher in the Cl group than in controls (P<0.001).

Conclusions: Our study suggests that Pvull and Ser447Ter polymorphisms are associated with lipid profile and Cl. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Current cognitive models suggest that the processing of dynamic facial attributes, including social signals such as gaze

direction and facial expression, involves the superior temporal sulcus, whereas the processing of invariant facial structure such as the individuals’ identity involves the fusiform face area. Where facial attractiveness, a social signal that may emerge from invariant facial structure, is processed within SCH772984 this dual-route model of face perception is uncertain. Here, we present two studies. First, we investigated Selleck MK-1775 the explicit judgments of facial attractiveness and attractiveness-motivated behavior in patients with acquired prosopagnosia, a deficit in familiar face recognition usually associated with damage to medial occipitotemporal cortex. We found that both abilities were impaired in these patients, with some weak residual ability for attractiveness judgments found only in those patients with unilateral right occipitotemporal or bilateral anterior temporal lesions. Importantly,

deficits in attractiveness perception correlated with the severity of the face recognition deficit. Second, we performed a functional magnetic resonance imaging study in healthy Selleck LY411575 subjects that included an implicit and explicit

processing of facial attractiveness. We found increased neural activity when explicitly judging facial attractiveness within a number of cortical regions including the fusiform face area, but not the superior temporal sulcus, indicating a potential contribution of the fusiform face area to this judgment. Thus, converging neuropsychological and neuroimaging evidence points to a critical role of the inferior occipitotemporal cortex in the processing of facial attractiveness. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Nutrient transporters and ABC efflux pumps at the blood-brain barrier are major determinants of drug penetration into the brain. Immunohistochemical analysis of transporter subcellular localization is challenging due to the close apposition of the luminal and abluminal microvessel plasma membranes. We employed in vivo perfusion of biotinylation reagent through rat brain microvessels to domain-specifically label proteins exposed on the microvessel luminal surface. Using this approach, we analyzed the luminal/abluminal localization of a number of blood-brain barrier transporters identified by quantitative PCR profiling as being highly expressed and enriched in rat brain endothelial cells compared with whole brain. We also examined the apical/basal-lateral distribution of transporters in the choroid plexus, a secondary site for transport of nutrients between the blood and CNS.