05). There was no meaningful difference between congenital and acquired cholesteatoma with respect to p21 expression. There was significant difference between congenital and acquired cholesteatoma regarding p53.

Conclusion: Up-regulation of

p21 protein is expected to play a significant role in CC development. Apoptosis is an important process in the pathogenesis of congenital cholesteatoma. It seems reasonable to perform studies on apoptosis in congenital cholesteatoma in the prospective way taking into consideration more specimens.”
“Unilateral absence of a pulmonary artery is a rare anomaly. Patients may present with hemoptysis, NU7441 manufacturer recurrent respiratory infections, pulmonary hypertension, or congestive heart failure. This report describes the FAK inhibitor case of a missing right pulmonary artery associated with anomalous left pulmonary venous connection not previously described in the medical literature.”
“Primary hemifacial spasm (HFS) is characterized by irregular and involuntary contraction

of the muscles innervated by the ipsilateral facial nerve. Treatment controls symptoms and improves quality of life (QoL). Objective: Evaluate the initial diagnosis and treatment of HFS prior to referral to a tertiary center. Method: We interviewed through a standard questionnaire 66 patients currently followed in our center. Results: Mean CT99021 in vivo age: 64.19 +/- 11.6 years, mean age of symptoms onset: 51.9 +/- 12.5 years, male/female ratio of 1:3. None of the patients had a correct diagnosis in their primary care evaluation. Medication was prescribed to 56.8%. Mean time from symptom onset to botulinum toxin treatment: 4.34 +/- 7.1 years, with a 95% satisfaction. Thirty percent

presented social embarrassment due to HFS. Conclusion: Despite its relatively straightforward diagnosis, all patients had an incorrect diagnosis and treatment on their first evaluation. HFS brings social impairment and the delay in adequate treatment negatively impacts QoL.”
“Objective: To report preliminary results of a new closed-skin, transcutaneous bone conduction device (BCD) in 6 children with high-grade ear atresia

Settings: Tertiary care center; prospective study; we evaluated the gain with masking of the contralateral ear and the benefit of hearing rehabilitation with the transcutaneous BCD in noise: speech-in-noise tests, conducted in real life condition (with contralateral ear unmasked and fitted with a hearing device if done before implantation), with and without BCD, with determination of the speech reception threshold (SRT). Children and parent’s satisfaction was assessed.

Results: Patients’ ages ranged from 6 to 9 years. All had high-grade ear atresia with a preoperative mean pure-tone average (PTA) loss of 71.46 +/- 6.59 dB on air conduction and 14 +/- 4.98 dB on bone conduction.