4 41.6 42.9 43.3 38.3 More than one PRIMA-1MET weekly   13.1 12.7 12.9 14.1 13.6 Smoking (%) Never   60.5 59.6 60.2 61.6 61.9 Past   29.8 28.6 30.1 30.2 31.4 Current   9.6 11.8 9.7 8.2 6.6 Frequency goes outdoors (%) 2+/day   64.6 65.6 63.6 62.7 65.1 ≥2/week but ≤ 1/day   34.2 33.5 35.5 35.8 33.1 ≤1/week   1.2 0.9 0.9 1.5 1.7 Frequency leaves the neighborhood (%) 2+/day   14.1 14.2 13.4 12.5 15.8 ≥2/week but ≤ 1/day   76.7 77.0 77.6 78.1 74.5 ≤1/week   9.1 8.8 8.9 9.3 9.8 On-feet ≤ 4 hours/day, %   9.2 8.5 9.4 8.2 10.8 Physical activity in past year, in (kcal)   1,614 (1,646) 1,598 (1,598) 1,577 (1,560) 1,633 (1,708) 1,668 (1,770) Hours/week

does household chores   8.6 (9.3) 9.0 (9.5) 8.4 (9.0) 8.7 (9.6) 7.8 (8.8) Values are mean (SD) or percent Fig. 1 Distribution of cumulative falls in the sample Factors that were associated with fall rates in the final multivariate model (p ≤ .05) are shown in Table 2. Fall rates were two times higher among women with a history of falls at baseline PI3K inhibitor compared to women with no prior history of falls and 62% higher among women who had used AED as compared to women who had never used AED. Table 2 Factors associated with fall rates in multivariate-adjusted models, N = 8,378  

Relative risk (95% confidence interval)a Base modelb Full modelc Demographics and

Pregnenolone anthropometrics  Taller height, per 5 in. 0.95 (0.92, 0.98) 0.89 (0.82, 0.96) Geriatric conditions  Staurosporine Dizziness upon standing 1.29 (1.18, 1.41) 1.16 (1.06, 1.27)  Fear of falling 1.37 (1.27, 1.47) 1.20 (1.11, 1.29)  Visual acuity, unit = 2 SD 0.83 (0.77, 0.90) 0.87 (0.81, 0.94)  Self-rated health decline 1.48 (1.31, 1.66) 1.19 (1.04, 1.35)  Fall history at baseline 2.28 (2.12, 2.46) 2.05 (1.91-2.21) CNS-active medications  Use of benzodiazepines 1.27 (1.14, 1.40) 1.11 (1.01, 1.23)  Use of antidepressants 1.45 (1.20, 1.75) 1.20 (1.00, 1.45)  Use of antiepileptics 1.77 (1.41, 2.22) 1.62 (1.31, 2.02) Physical function  Number of IADL with difficulty, unit = 1 1.21 (1.17, 1.25) 1.12 (1.07, 1.17)  Standing balance, eyes closed (vs. poor)  Fair 0.82 (0.76, 0.89) 0.95 (0.88, 1.04)  Good 0.73 (0.65, 0.81) 0.85 (0.76, 0.95)  Faster usual walking speed, unit = 2 SD 0.84 (0.77, 0.91) 1.18 (1.08-1.30) Lifestyle  Smoking status (vs. never)       Past 1.04 (0.96, 1.13) 1.06 (0.98, 1.15)   Current 0.82 (0.71, 0.95) 0.76 (0.66, 0.88) Physical activity (kcal; vs.