6 1 A UvrA (H pylori 26695 HP0705, C jejuni NCTC11168 Cj0342c

6.1. A. UvrA (H. mTOR inhibitor pylori 26695 HP0705, C. jejuni NCTC11168 Cj0342c, E. coli K12 EG11061

and S. aureus N315 SA0714). B. UvrB (H. pylori 26695 HP1114, C. jejuni NCTC11168 Cj0680c, E. coli K12 EG11062 and S. aureus N315 SA0713. C. UvrC (H. pylori 26695 HP0821, C. jejuni NCTC11168 Cj1246c, E. coli K12 EG11063 and S. aureus N315 SA0993). D. UvrD (H. pylori 26695 HP1478, C. jejuni NCTC11168 Cj1101, E. coli K12 EG11064 and S. aureus N315 SA1721). The UvrD equivalent protein in Gram positive bacteria is known as PcrA. Amino acids conserved in three or all four orthologs are labelled with light or dark blue shading, respectively. (PDF 842 KB) Additional file 4: Table S1. Bacterial strains [12, 21, 39, 40]. Table S2. Oligonucleotide primers and PCR products used in this study [12, 44]. Table S3. Plasmids used in this find more study [12, 23, 43–45, 52]. (DOC 160 KB) References 1. Suerbaum S, Michetti P: Helicobacter pyloriinfection. N Engl J Med 2002, 347:1175–1186.PubMedCrossRef 2. Langenberg W, Rauws EA, Widjojokusumo A, Tytgat GN, Zanen HC: Identification ofCampylobacter pyloridisisolates by restriction endonuclease DNA analysis. J Clin Microbiol 1986,

24:414–417.PubMed 3. Majewski SI, Goodwin CS: Restriction endonuclease analysis of the genome ofCampylobacter pyloriwith a rapid extraction method: evidence for considerable genomic variation. J Infect Dis 1988, 157:465–471.PubMedCrossRef Adavosertib nmr 4. Bjorkholm B, Sjolund M, Falk PG, Berg OG, Engstrand L, Andersson DI: Mutation frequency and biological cost of antibiotic resistance inHelicobacter pylori. Proc Natl Acad Sci U S A 2001, 98:14607–14612.PubMedCrossRef 5. Kersulyte D, Chalkauskas H, Berg DE: Emergence of recombinant strains ofHelicobacter pyloriduring human infection. Mol Microbiol 1999, 31:31–43.PubMedCrossRef 6. Suerbaum S, Smith JM, Bapumia K, Morelli G, Smith NH, Kunstmann E, Dyrek I, Achtman M: Free recombination withinHelicobacter pylori.

Proc Natl Acad Sci U S A 1998, 95:12619–12624.PubMedCrossRef 7. Morelli G, Didelot X, Kusecek B, Schwarz S, Bahlawane C, Falush D, Suerbaum S, Achtman M: Microevolution ofHelicobacter pyloriduring prolonged infection of single hosts and within families. PLoS ALOX15 Genet 2010, 6:e1001036.PubMedCrossRef 8. Kang J, Blaser MJ: Bacterial populations as perfect gases: genomic integrity and diversification tensions inHelicobacter pylori. Nat Rev Microbiol 2006, 4:826–836.PubMedCrossRef 9. Fischer W, Prassl S, Haas R: Virulence mechanisms and persistence strategies of the human gastric pathogenHelicobacter pylori. Curr Top Microbiol Immunol 2009, 337:129–171.PubMedCrossRef 10. Suerbaum S, Josenhans C: Helicobacter pylorievolution and phenotypic diversification in a changing host. Nat Rev Microbiol 2007, 5:441–452.PubMedCrossRef 11. Kraft C, Suerbaum S: Mutation and recombination inHelicobacter pylori: mechanisms and role in generating strain diversity. Int J Med Microbiol 2005, 295:299–305.PubMedCrossRef 12.

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