liver stiffness; 4. elastography; Presenting Author: OM PARKASH Corresponding Author: OM PARKASH Affiliations: aga Khan University Karachi Objective: Malnutrition in cirrhotic patients is responsible for higher morbidities and mortalities and extent of malnutrition/ under-nutrition in cirrhotic patients in Pakistan is not known. Therefore it is mandatory to investigate burden of malnutrition in cirrhosis and their quality of life. Methods: This was cross sectional study on cirrhotic patients visiting outpatient clinics of Aga Khan University and Jinnah post graduate medical

center Karachi in ward 7 in 2010-12. Malnutrition was assessed by protein calorie malnutrition score (PCM), Anthropometry and Bio-electrical impedance (BIA). Subjects were divided into mild, moderate and severe malnutrition. Quality of life was assessed by using the health related quality of life (HRQOL) questionnaire this website Results: 148 cirrhotic subjects were included in study, 70 (47.3%) learn more were male and mean age of subjects was 49.1 ± 11 years. 138 (87.8%) had viral associated liver cirrhosis. Majority of the study subjects had child A (n = 61; 44.5%) and B (n = 59; 43.1%). In anthropometry, mean weight (kg) was 61.11 ± 12.48; height (meters) was 1.64 ± 0.07, bodymass index (BMI) was 22.34 ± 5.9, midarm circumference was 26.40 ± 4.15 cm, triceps skind thickness 27.3 ± 10.43 mm. Bioelectrical impedance showed total body water (Kg) 34.99 ± 7.51, fat free mass (kg)

45.6 ± 12.09, total body fat percentage was 22.27 ± 10.79. Mean Protein calorie malnutrition (PCM) score was 91.20 ± 16.70. The PCM showed malnutrition in approximately 109 (73.6%) subjects; mild in 72(48.4%), moderate 34(23%) and severe in 3 (2%). 57(35.4%) had poor quality of life. There is significant correlation of PCM score with BIA parameters (TBW, FFMI, Fat% etc) and there is not significant correlation between PCM and HRQOL. Conclusion: We conclude that majority of the patients with liver cirrhosis had malnutrition as assessed by PCM score as well as BIA and anthropometry Key Word(s): 1. liver cirrhosis; 2. malnutrition; 3. HRQOL; 4. BIA; Presenting Author: CECILLEMERCADO MALIJAN Additional Authors: IAN HOMERYEE CUA

Corresponding Author: CECILLEMERCADO MALIJAN Affiliations: St. luke’s Medical center Objective: Hepatic encephalopathy is a selleckchem serious neuropsychiatric condition occurring in patients with liver disease. The efficacy of rifaximin is well documented in the treatment of acute hepatic encephalopathy, but its efficacy for prevention of the disease has not been established. This meta-analysis aims to review data concerning the efficacy and safety of Rifaximin in comparison to conventional oral therapy in the treatment of cirrhotic patients with hepatic encephalopathy. Methods: We performed a systematic review and random effects meta-analysis of all eligible trials identified through electronic and manual searches. Two authors independently assessed trial quality and extracted data.