to the laSion’s cancer c Lon erh Ht, probably due to the lack of polyposis coli gene adenomatosis. One study showed Nakagawa hyper HDAC expression in a variety of cell lines in culture and a variety of prim Ren human lung, Speiser Lead, stomach, heart lon, pancreas, breast, ovarian and thyroid with. Top-level class AB1010 Masitinib I HDAC expression was observed in 75 of the feeder hre, Stomach, heart and prostate lon, and found the corresponding adjacent normal tissues. Cancer of the feeder Hre and prostate cancer tends consistent overexpression of HDAC class I have, other studies suggest a correlation between advanced lung cancer and high expression of class 1 HDAC 1 and tumor histology with aggressive, advanced stage of disease and poor prognosis in patients pancreatic cancer.
C Several retrospective studies on cancer cells Lon prim Ren performed showed a high level of expression of HDAC 1 and 2 in gastric cancer, the h HIGHEST expression with lymph node XL880 involvement, correlated undifferentiated histology and poor prognosis. High expression of HDAC 1, 2 and 3 was 70, observed 74, 95 and 192 of prostate cancer in a Hnlichen study, wherein overexpression of HDAC 1 and 2 or with HDAC tumor correlates poorly differentiated. Expression of high levels of cooperation between the three HDAC was associated with an increased proliferation index, w While the overexpression of HDAC 2 alone is a independent Ngiger Pr Predictor of poor prognosis. HDAC-2 overexpression is correlated with an advanced stage of the disease and reduced survival rate of patients with oropharyngeal cancer.
In contrast, HDAC 1 expression in breast cancer with expression of estrogen receptors And progestin in the early stages of the disease and a better answer to the survival of the patient associated with tamoxifen and HDAC 6 expression associated with the survival of the patient. HDAC expression in h Increased dermatological malignancies in malignant h Dermatological diseases Ht HDAC activity t To the repression of transcription of genes critical for h Lead matopoetische differentiation Ethics plays an r Crucial role in the pathogenesis of leukemia premiums Several. In the case of acute leukemia Mie promyelocytic, the protein product of the PML RAR t translocation and core binding factor in the product of the gene AML1 ETO Leuk mie caused product of t and CBF MYH 11, the repression of transcription, HDAC recruitment gene promoter regions LCT cells aberrant through h here apoptosis normal lymphocytes responsive to HDAC inhibitor treatment.
Sodium butyrate and tricostatin A induced apoptosis of myeloid leukemia Mie Acute and a CML cell line, down-regulation of the expression of Daxx, 2 without the expression of Bcl or Bcl XL. A recent study reported a antileuk Chemical activity T of Valproins Ure Only by the induction of apoptosis in primary leukemic Ren Mix cells of 14 patients receive. These results support the development of drugs that HDACi the catalytic region of HDAC block interact HDAC activity t ar induce differentiation, cell growth