A unique model of relapse was observed in TNBC: in the first two years foll Diagnosis, BMS-387032 SNS-032 because it follows a rapid increase in the rate of recurrence, with a peak in three years from a rapid decline in the n Next five years, and a very low risk of a sp Lower offense. The location of relapse requires some discussion. In particular, whether the local regional recurrence h Ago as the basis for other diseases subtypes is discussed, with some studies showing no significant high RLP and other Erh Increase the risk to find PBA separated after breast-conserving surgery.
The model of metastatic relapse was examined in a series of studies, and relapse in lung tissue and soft, it was found that h More frequently lymph node metastases as a relapse or bone There is also an h Higher risk of brain metastases has been associated with Dasatinib pulmonary metastases associated with a worse prognosis Because many studies no relationship between an increase in Tumorgr s and an increase increase of node positive disease and found since have TNBC This Ph nomen was also shown to exist in BRCA-associated cancers, it has been hypothesized that the Base as a disease, a pattern of h matogenen spread Loco regional cancer triple negative breast cancer in triple-negative breast have is in younger women, African Americans, women of Jewish origin, and women diagnosed with a family history of breast cancer or high-risk ovarian cancer, should BRCA tests are included as part of the pre-treatment. For those who are positive for BRCA and BRCA mutation are often advised to undergo a bilateral mastectomy, especially if they are young.
Au He are of this subgroup of patients, considerations for the choice of treatment for locoregional TNBC the same as for other ductal carcinomas. Breast-conserving surgery with postoperative radiotherapy is the treatment of choice for the local women with T and T TNBCs. Mastectomy is reserved for women with multicentric disease or involved margins after excision re st Constantly. Women with TNBC still be large e candidates for breast conserving surgery that studies such as n The extreme sensitivity of TNBC demonstrated to neoadjuvant chemotherapy and reduce the size S the tumor after neoadjuvant treatment. Mastectomy radiation is generally not necessary if the tumor cm or more margins are involved, or if you have lymph node metastases, but Tseng et al that adjuvant radiotherapy is recommended in all patients with metaplastic breast cancer may lead to an improved survival rate.
Voduc et al have suggested that basal like breast cancer and HER-positive breast lokoregion the worst year survival rate Re compared to other molecular subtypes of breast cancer after breast-conserving surgery have. This raises concerns about breast-conserving surgery in women with TNBC. However, the same study showed that the rate of loco regional recurrence years after mastectomy h Forth in TNBC and basal positive breast cancer was. Therefore, the recurrence rate is low survival observed in women more likely the result of the biology of TNBC, and may be less likely to be determined by the type of operation.