Ellis, MD, PhD (PI), J. Allen McCutchan, MD, Scott Letendre, MD, Edmund Capparelli, PharmD, Rachel Schrier, PhD; Neurobehavioral Component: Robert K. Heaton, PhD (PI), AP24534 Mariana Cherner, PhD, David J. Moore, PhD, Steven Paul Woods, PsyD; Neuroimaging Component: Terry Jernigan, PhD (PI), Christine Fennema-Notestine, PhD, Sarah L. Archibald, MA, John Hesselink, MD, Jacopo Annese, Inhibitors,research,lifescience,medical PhD, Michael J. Taylor, PhD, Brian Schweinsburg, PhD; Neurobiology Component: Eliezer Masliah, MD (PI), Ian Everall, FRCPsych, FRCPath, PhD, T. Dianne Langford, PhD; Neurovirology Component: Douglas Richman, MD, (PI), David M. Smith, MD; International Component: J. Allen McCutchan, MD, (PI);

Developmental Component: Ian Everall, FRCPsych, FRCPath, PhD (PI), Stuart Lipton, MD, PhD; Inhibitors,research,lifescience,medical Clinical Trials Component: J. Allen McCutchan, MD, J. Hampton Atkinson, MD, Ronald J. Ellis, MD, PhD, Scott Letendre, MD; Participant Accrual and Retention Unit: J. Hampton Atkinson, MD (PI), Rodney von Jaeger, MPH; Data Management Unit: Anthony C. Gamst, PhD (PI), Clint Cushman, BA, (Data Systems Manager), Daniel R. Masys, MD (Senior Consultant); Statistics Unit: Ian Abramson, PhD (PI), Florin

Vaida, PhD, Christopher Ake, PhD. The views expressed in this article Inhibitors,research,lifescience,medical are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government.
The bipolar states of mania and depression have a clear impact on cognitive function. The clinical criteria for mania fairly include distractibility, inappropriate Inhibitors,research,lifescience,medical speech and behavior, increased goal-directed behavior, and a tendency to make decisions associated with potential painful consequences.1 The depressive state is also characterized by cognitive changes, including a lack of concentration, difficulty making decisions, Inhibitors,research,lifescience,medical motor slowing, and changes in memory. Understanding the brain changes that, accompany

these illness states is an important target for psychiatric neuroscience, for a number of reasons. The identification of illness markers for bipolar disorder will facilitate the early detection of bipolar episodes, which may spare patients and their families considerable distress. Cilengitide Earlier detection of the illness itself is also of significant, benefit: bipolar disorder continues to be frequently misdiagnosed as Major Depressive Disorder in individuals without, a clear history of manic episodes,2,3 with the consequence that, patients may be maintained on a suboptimal medication regime until their bipolar diathesis is noticed. Second, characterizing the profile of brain dysfunction in bipolar disorder will also help identify novel targets for pharmacological treatment, and may eventually allow identification of individuals at high risk for developing bipolar disorder.