Furthermore creatine supplementions did not change PCr/ATP ration

Furthermore creatine supplementions did not change PCr/ATP rations in sedentary healthy subjects, patients with chronic progressive external

ophthalmoplegia (CPEO), X-chromosomal Becker type muscular dystrophy (BMD) and Friedreich ataxia (13–15). However, athletes performing daily physical training profit from creatine by an elevated PCr/ATP ratio and by enhancements Inhibitors,research,lifescience,medical in physical performance (15–17). In various neuromuscular disorders reduced concentrations of the creatine transporter protein was found (18). One may conclude that only in physically training muscles which underwent growth or elevated turn over in terms of regeneration a net uptake of creatine and the conversion to PCr takes place (15). In terms of improvements in symptomatic and muscle performance Inhibitors,research,lifescience,medical patients with GSG V profit only from low dose creatine supplementation. The high dose sup this website plementation study was nearly unblinded by worsen symptomatic of patients by creatine (7, 19). Since muscle most likely

did not take up creatine from blood, effects independent from muscle energy metabolism may cause both the positive and the negative effects of creatine on patients symptomatic. Negative effects of creatine supplementation in terms of more frequent muscle pain or even cramps Inhibitors,research,lifescience,medical were also found in some patients with CPEO (13). Positive effects Inhibitors,research,lifescience,medical by creatine on muscle performance likely independent from an increase in muscle PCr content were found in a patient with Duchenne muscle dystrophy (20). In advance of creatine supplementation, calf muscle of this patient fatigued at moderate contraction without 31PMRS visible consumption of PCr. During supplementation, muscle performance significantly improved in terms of force and endurance and PCr was nearly depleted during muscle testing before muscle reached fatigue. Nutritional creatine supplementation is a legal ergogenic measure in sports supporting training aiming at high muscle force and power. However, athletes performing endurance sports do Inhibitors,research,lifescience,medical not profit from creatine (16). Even in

athletes, rare negative side effects of oral creatine supplementation have become known similar to the negative Thalidomide symptoms that have been observed in supplemented patients. Due to the very high number of athletes using creatine and due to the very few cases of negative side effects benefits seem to overwhelm the risks (16, 21, 22). Future studies have to test whether patients with GSD V may profit from high dose creatine supplementation when they also perform some kind of sport inducing muscle growth. Recent studies have shown that patients with GSD V are tolerant to aerobic exercise training and become more tolerant when supplemented with acute carbon hydrate supplementation (23, 24). Patients with GSD V may also tolerate a specific resistive strength training.

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