In this study, we assessed clinical and pathological features of Max GD in IgA nephropathy using regression analysis. Methods: Forty

three patients diagnosed with IgAN and eGFR ≥ 50 mL/min/1.73 m2 since March 1993 to September 1998 were registered. We investigated the correlations between MaxGD and baseline histological data, clinical data, 10-year follow-up data using regression analysis. Results: In histopathology, Max GD was significantly correlated with arteriolosclerosis (R = 0.44, p = 0.003). In clinical factors, Max www.selleckchem.com/products/abc294640.html GD was significantly correlated with body mass index (R = 0.51, p = 0.0004), age (R = 0.42, p = 0.006), follow-up proteinuria (R = 0.46, p = 0.002)(Figure), eGFR decline per year(R = 0.33, p = 0.03). Conclusion: Max GD was an ideal marker for morbid glomerular hypertrophy which was associated with obesity and a prognostic indicator for disease progression in IgAN patients. LUO YANKUN1,2, INOUE TSUTOMU1, SUZUKI HIROMICHI1, OKADA HIROKAZU1 1Department of Nephrology, Faculty of Medicine, Saitama Medical University, Irumagun, Japan; 2Department of Nephrology, Shanxi Provincial People’s Hospital, Shanxi, China Introduction: Two types of global Selleckchem CH5424802 glomerulosclerosis, i.e., glomerular obsolescence (OBS) and solidification (SLD) have been identified especially, but not specifically, in hypertensive nephrosclerosis (HNS). Clinicopathological

correlation of these glomerular changes in HNS was demonstrated, however, those in other kidney diseases such as IgA nephropathy (IgAN) remain to be clarified. Methods: A retrospective, clinicopathological PJ34 HCl analysis of biopsy proven IgAN (n = 67) was performed. Results: Clinical parameters of the employed patients with IgAN were M/F, 33/34; age, 39.0 ± 15.4 [year-old]; systolic BP, 126.8 ± 16.3 [mmHg]; diastolic BP, 81.2 ± 13.3 [mmHg]; BMI, 23.2 ± 5.1; serum Cr, 0.90 ± 0.42 [mg/dL]; eGFR, 74.4 ± 25.7 [mL/min/1.73 m2]; total Chol, 215.1 ± 70.5 [mg/dL]; and

proteinuria, 2.45 ± 4.07 [g/gCr]. The incidence rates of OBS and SLD ( (No. of OBS (SLD))/(No. of total glomerulus)x100) in the kidney biopsies from patients with IgAN were variable (5 ± 11[%] and 4 ± 9[%], respectively). They were not correlated with age, BMI, eGFR, or TChol levels. In contrast, either BP levels or proteinuria was correlated with the incidence rates of SLD, but not OBS. Conclusion: In this study, two types of global glomerulosclerosis were seen in IgAN. Based on the previous analysis in HNS, OBS was regarded as the consequence of ischemia due to narrowing of intrarenal vessels while SLD was presumed to be associated with excessive autoregulatory responses and genetic factors. If it is true, since the incidence rates of SLD was better correlated with some nephritis-related clinical parameters than those of OBS in IgAN, the emergence of SLD may influence on the clinical activities of IgAN.