In women with CD, the rate of new clinically recorded fertility problems was highest in the 25–29 year age group (12.5 per 1000 person-years), and in women without CD

the rate was highest in the 30–34 year age group (12.6 per 1000 person-years). Across all age groups, however, there were no statistically significant differences between the rates of new clinically recorded fertility problems Protease Inhibitor Library price in women with and without CD (eg, IRR in the 25–29 year age group, 1.12; 95% CI, 0.88–1.42; IRR in the 30–34 year age group, 0.87; 95% CI, 0.70–1.08). Of the 290 women who had CD and a recorded fertility problem, 122 (42%) were classified as having undiagnosed CD and 168 (58%) were classified as having diagnosed CD in relation to the new clinically recorded fertility problem. The diagnosis of CD happened at a median of 2 months after the fertility problem (IQR,

4 years before, 2.7 years after). Figure 1 shows the time of new clinically recorded fertility problems in relation to the CD diagnosis. Approximately a quarter of the fertility problems were recorded within a year before or after the CD diagnosis, with 5% being recorded within a year before Lumacaftor clinical trial the fertility problem and 19% within a year after the fertility problem. Overall, the age-specific rates of new clinically recorded fertility problems were higher in women with diagnosed CD compared with women with undiagnosed

CD (15.4 per 1000 person-years in diagnosed CD compared with 9.8 per 1000 person-years in undiagnosed CD in the 25–29 year age group) (Table 2). There was no statistically significant difference between the rates of new clinically recorded fertility problems in women with both undiagnosed and diagnosed CD compared with women without CD, except for the 25–29 year age group, in which women with diagnosed CD were oxyclozanide 41% more likely to have new clinically recorded fertility problems compared with women without CD (IRR, 1.41; 95% CI, 1.03–1.92). However, the absolute excess risk was only 0.5% (5.2 per 1000 person-years). Of the 6506 women with celiac disease, 1143 (17.6%) were recorded as symptomatic (with weight loss, diarrhea, or anemia) in the year before diagnosis. The age-specific rates of new clinically recorded fertility problems in this subset of women with symptomatic celiac disease were not statistically significantly different compared with women without celiac disease. The overall rate was found to be 40% lower, however, the absolute risk difference was only 2.3% (Table 2). Of 6506 women with CD, 4649 (71.4%) had received a gluten-free prescription. Of these women, 211(4.5%) had clinically recorded fertility problems, which was almost exactly the same as in the overall population.