J Biol Chem 1998,273(29):18268–18272.selleck PubMedCrossRef 14. Webb DJ, Nguyen DH, Sankovic M, Gonias SL: The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro. J Biol Chem 1999,274(11):7412–7420.PubMedCrossRef LXH254 mouse 15. Webb DJ, Nguyen DH, Gonias SL: Extracellular signal-regulated kinase
functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion. J Cell Sci 2000,113(Pt 1):123–134.PubMed 16. Yu W, Kim J, Ossowski L: Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy. J Cell Biol 1997,137(3):767–777.PubMedCrossRef 17. Seddighzadeh M, Zhou JN, Kronenwett U, Shoshan MC, Auer G, Sten-Linder M, et al.: ERK signalling in metastatic
human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation. Clin Exp Metastasis 1999,17(8):649–654.PubMedCrossRef 18. Holst-Hansen C, Johannessen B, Hoyer-Hansen G, Romer J, Ellis V, Brunner N: Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasiveness. Clin Exp Metastasis 1996,14(3):297–307.PubMed 19. Mhaidat NM, Thorne RF, Zhang XD, Hersey P: Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C. Mol Cancer Res 2007,5(10):1073–1081.PubMedCrossRef 20. Yacoub A, Han SI, Caron R, Gilfor D, Mooberry S, Grant selleck screening library S, et al.: Sequence dependent exposure of mammary carcinoma cells to Docetaxel and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro. Cancer Biol Ther 2003,2(6):670–676.PubMed 21. Davies BR, Logie A, Mckay JS, Martin P, Steele S, Jenkins R, et al.: AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases:
mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol cAMP Cancer Ther 2007,6(8):2209–2219.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions JL did the cell invasion essay and immunohistochemistry, XS did the Cell-culturing, submitted paper and revised the paper, FG did the medical statistics, XZ cultured the cell and did PCR, BZ tested the cells in PCR, HW detected the cells in western blot, ZS designed this experiment and wrote this paper. All authors read and approved this final draft.”
“1. Introduction Human gliomas are the most common primary intracranial tumors in adults. A grading scheme proposed by the WHO distinguishes four different grades of gliomas, of which glioblastoma multiforme (GBM) WHO grade IV is the most malignant variant with a median survival time of 1 year .