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mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models. Mol cAMP Cancer Ther 2007,6(8):2209–2219.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions JL did the cell invasion essay and immunohistochemistry, XS did the Cell-culturing, submitted paper and revised the paper, FG did the medical statistics, XZ cultured the cell and did PCR, BZ tested the cells in PCR, HW detected the cells in western blot, ZS designed this experiment and wrote this paper. All authors read and approved this final draft.”
“1. Introduction Human gliomas are the most common primary intracranial tumors in adults. A grading scheme proposed by the WHO distinguishes four different grades of gliomas, of which glioblastoma multiforme (GBM) WHO grade IV is the most malignant variant with a median survival time of 1 year [1].

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