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“1 Introduction The treatment of mental disorders usually requires prolonged pharmacotherapy in order to resolve the current episode and reduce the risk for recurrence of symptoms, while addressing the challenges of low compliance in the long term. Such AZ 628 prolonged therapy requires considerable commitment on the part of patients to take their medication as prescribed. Medication compliance is often challenging among psychiatric patients, including those with schizophrenia or bipolar disorder; this can be associated with poor long-term outcomes and, ultimately, treatment failure [1]. A greater understanding of patients’ preferences

for new formulations of treatment is central to current models of shared patient–doctor decision making, and has gained considerable interest in scientific research for orodispersible formulations of antidepressants and antipsychotics [2]. The effectiveness of the antipsychotic drug SBI-0206965 ic50 olanzapine classic oral tablet

in the treatment of patients with schizophrenia has been widely investigated in several randomized, controlled trials, and observational studies [3–7] Calpain and in several meta-analyses [8, 9]. In recent years, more clinical attention has been paid to oral dispersible tablet formulation of medications [10]. Lyophilized (freeze dried), orally disintegrating olanzapine is a rapid dissolving formulation of olanzapine that disintegrates in saliva almost instantaneously. The formulation was developed as a convenient, easy to ingest and potentially adherence-enhancing alternative to the standard olanzapine coated tablet. Pharmacokinetic studies have shown that the olanzapine orodispersible tablet (ODT) is bioequivalent to olanzapine standard tablet with the same rate and extent of bioavailability [11]. Clinical studies have shown that olanzapine ODTs and standard olanzapine tablets have similar efficacy and tolerability profiles; however, olanzapine ODTs appear to have a number of advantages over olanzapine standard tablets in terms of adherence, patient preference and reduction in nursing burden [2, 12, 13].