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blocks ovarian cancer cell and tumor growth. DNA Repair 2008, 7:177–186.PubMedCrossRef 28. Kuwai T, Kitadai Y, Tanaka S, Kuroda T, Ochiumi T, Matsumura S, Oue N, Yasui W, Kaneyasu M, Tanimoto K, et al.: Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma. Oncol Rep 2004, 12:1033–1037.PubMed 29. Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DC: Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res 2008, 14:612–617.PubMedCrossRef 30. Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC: VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:856–862.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions KSJ performed the molecular genetic eFT508 order studies and drafted the manuscript.

KIJ participated in preparation of the manuscript. LMK and LCH participated in the design of the study and LSY performed the statistical analyses. LEY and HSH conceived the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background External beam radiotherapy to the pelvis is related to the development of radiation colitis which is a consequence of radiation-induced mucosal and bowel wall injury. Although in recent years radiation techniques have improved with regard to best dosimetric accuracy, radiation toxicity remains a significant clinical problem resulting in treatment delays,

increased patient hospitalisation rates and remarkable HDAC inhibitor short and long-term morbidity [1, 2]. LY333531 chemical structure Prevention of radiation-induced bowel injury has been the focus of several studies. Among regimens so far investigated one of the best-known radioprotectors is considered to be amifostine. Amifostine is an organic thiophosphate cytoprotective agent known chemically as 2-[(3-aminopropyl) amino] ethanethiol dihydrogen phosphate (ester) [3]. The ability of amifostine to protect normal tissues is attributed to the higher capillary alkaline phosphatase activity, higher pH and better vascularity of normal tissues compared to tumour tissue, resulting in a more rapid generation of the active thiol metabolite and thereby detoxifying the reactive metabolites and scavenging reactive oxygen species generated by radiation [4].