Lacosamide zure freed seizure im-provemen or no change. Data were expressed as median for continuous variables and counts for categorical variables. Differences between responders and nonresponders werepared using an unpaired t te analysis of varian and Wilcoxon rank sum tests for continuous measures and and Fisher exact tests for categorical variables. RESULTS CLINICAL CHARACTERISTICS Clinic radiologic E autoimmune serologic val-u and immunotherapeutic oues for 2 patients are presented in Table and Table . All presented with recurrent seizures. Fifty-nine percent were female. Me-dian seizure onset age was years . Median history of seizure activity prior to Mayo Clinic presentation was months . An autoimmune basis was suspected based on detection of a neural autoantibod inflammatory CSF , or MRI characteristics suggesting in-flammation . SEIZURE AND EEG CHARACTERISTICS Partial seizures were the predominant clinical presenta-tion: simple partial and/or aur 7 of  plex parti 6 of . and  AZD2171 secondary generalized tonic-clon 7 of 2 .

Seizure semiologies were variable or changed over time in 2 patients . Most patients had received or more AEDs at presen-tatio yet seizures were frequent: 6 had daily seizures; the remaining had at least seizure per month. Two patients had undergone epilepsy surgery with-out seizure benefit elsewher. none had a neoplasm. Perivascular chronic  glucitol 50-70-4 inflammatory cell infil-trates were noted on histopa-thology review at our institution in patient ; details for the other patient are unavailable. Continuation of poorly ARCH NEUROL PUBLISHED ONLINE MARCH 6, WWW.ARCHNEUROL Downloaded from www.archneurol at Mt Sinai School Of Medici on March 9, American Medical Association. All rights reserved. Table . Clinical Characteristics a Post-ITX Seizure No. of MRI ITX Changes b c Profile d,e Treatments Duration) Antibody Titer M 5 SPS: bilateral Cognitive Daily IED L medial Normal VGKC IVIg temporal ple Lg , week );

IVM. freedom diffuse tingling; CPS  bicycli oral automatis unilateral limb posturing f Casp TPO PLE. MMF M Auras: de ′jfivu; CPS: Monthly Generalized slowing Protein level  buy Imiquimod VGKCplex No ITX; thyroid cancer detected Seizure freedom unresponsive starin Lg Casp and resected; neurologic symptoms subsided after cancer treatment F Changed over Cognitive; Daily IED R temporal OCB CRMP IVM. Seizure time; SPS  leg jerki UE jerking; EPC: personalit I. repeated cycles of IVMP owing to improve-ment; post-ITX CRMP continuous low amplitude R finger facial jerking; CPS: unresponsive staring; rare GTC f and extratem-pora F gener-alized slowing relapse. MMF M SPS: frequent Daily Normal Protein level CRMP IVM. Seizure episodes of olfactory hallucinos head pressu MMF freedo. post-ITX CRMP dysarthr then fatigue f M 4 g,h Changed over Monthly IED Post emporal WBC count VGKC IVM.

Seizure time; auras and CPS  diffuse hot sensati , F lobectomy gliosis; R MT protein level ple Lg , Casp IVI. freedo. post-ITX VGKC auditory hallucinosis; GTC f gener-alized slowing   cell theory MMF pl F 7 g GTC out of sleep Monthly IED Not done VGKC No ITX; seizures , gener-alized slowingple Lg Casp continued with first AED; subsequent change to second A with seizure freedom thereafter; eventually std taking all AEDs F EPC occipital origin: unilateral Cognitive.