: PerR confers phagocytic killing resistance and allows pharyngeal colonization by group A Streptococcus. PLoS Pathog 2008,4(9):e1000145.PubMedCrossRef 23. Lee JW, Helmann JD: The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation. Nature 2006,440(7082):363–367.PubMedCrossRef selleck products 24. Pulliainen AT, Haataja S, Kahkonen S, Finne J: PF-3084014 mw Molecular basis of H2O2 resistance mediated by Streptococcal Dpr: Demonstration of the functional involvement of
the putative ferroxidase center by site-directed mutagenesis in Streptococcus suis. J Biol Chem 2003,278(10):7996–8005.PubMedCrossRef 25. Aranda J, Garrido ME, Fittipaldi N, Cortes P, Llagostera M, Gottschalk M, Barbe J: The cation-uptake regulators AdcR and Fur HDAC inhibitor are necessary for full virulence of Streptococcus suis. Vet Microbiol 2010,144(1–2):246–249.PubMedCrossRef 26. Hillmann F, Fischer RJ, Saint-Prix F, Girbal L, Bahl H: PerR acts as a switch for oxygen tolerance in the strict
anaerobe Clostridium acetobutylicum. Mol Microbiol 2008,68(4):848–860.PubMedCrossRef 27. Horsburgh MJ, Clements MO, Crossley H, Ingham E, Foster SJ: PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus. Infect Immun 2001,69(6):3744–3754.PubMedCrossRef 28. Faulkner MJ, Ma Z, Fuangthong M, Helmann JD: Derepression of the Bacillus subtilis PerR peroxide stress response leads to iron deficiency. J Bacteriol 2012,194(5):1226–1235.PubMedCrossRef
29. Herbig AF, Helmann JD: Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA. Mol Microbiol 2001,41(4):849–859.PubMedCrossRef 30. Haikarainen T, Papageorgiou AC: Dps-like proteins: structural and functional insights into a versatile protein family. Cell Mol Life Sci 2010,67(3):341–351.PubMedCrossRef 31. Pulliainen AT, Kauko A, Haataja S, Papageorgiou AC, Finne J: Dps/Dpr ferritin-like protein: insights into the mechanism of iron incorporation and evidence for a central role in cellular Ribonuclease T1 iron homeostasis in Streptococcus suis. Mol Microbiol 2005,57(4):1086–1100.PubMedCrossRef 32. Haikarainen T, Thanassoulas A, Stavros P, Nounesis G, Haataja S, Papageorgiou AC: Structural and thermodynamic characterization of metal ion binding in Streptococcus suis Dpr. J Mol Biol 2010,405(2):448–460.PubMedCrossRef 33. Sasindran SJ, Saikolappan S, Dhandayuthapani S: Methionine sulfoxide reductases and virulence of bacterial pathogens. Future Microbiol 2007,2(6):619–630.PubMedCrossRef 34. Cabreiro F, Picot CR, Friguet B, Petropoulos I: Methionine sulfoxide reductases: relevance to aging and protection against oxidative stress. Ann N Y Acad Sci 2006, 1067:37–44.PubMedCrossRef 35. Ezraty B, Aussel L, Barras F: Methionine sulfoxide reductases in prokaryotes. Biochim Biophys Acta 2005,1703(2):221–229.PubMedCrossRef 36.