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Competing interests The authors declare that they have no competing interests. Authors’ contributions BMW, NP and MB designed and performed most of the experiments, VH, NP and GA contributed to SPR experiments, NP and DZB contributed to expression and cleavage experiments; Ibrutinib BD and MR contributed toward strain and genome selection. All authors contributed to analysis of the results and during the preparation of the manuscript.”
“Background Tannase (tannin acyl hydrolase, EC 3.1.1.20) specifically catalyzes the hydrolysis of the galloyl ester bonds in hydrolyzable tannins that occur widely in the plant kingdom and are considered to be a protective strategy against microbial attack [1]. The enzyme was first reported in fungal

genera (e.g. Aspergillus, Penicillium, and Candida[1]) and is used in tea, wine, and beer processing for removal of insoluble condensation products composed of caffeine and tea flavonoids, including catechins [2]. The first indication of bacterial tannase was reported more than buy Dolutegravir 20 years ago, based on methylgallate-hydrolytic activity observed in Streptococcus gallolyticus and Lonepinella koalarum found in the alimentary tract of koalas feeding on tannin-rich eucalyptus leaves, implying a possible symbiotic relationship between the animal and these bacteria [3–5]. To date, tannase production has been identified in other bacterial species [1], including lactobacilli species of Lactobacillus plantarum, Lactobacillus paraplantarum, and Lactobacillus pentosus, which were isolated from fermented vegetables [6, 7]. L. plantarum, L. paraplantarum, and L.