Soft tissue tumor was suspected and biopsy was performed. Initial colonoscopic histopathological examination revealed chronic proctitis with lymphoid aggregates and atrophy. For more confirmatic diagnosis, soft tissue tumor excision was performed under general anesthesia. Histopathological examination revealed plasma cell infiltration and fibrosis. Immunohistochemistry revealed prominence of IgG4-positive plasma cells and confirmed the diagnosis of IgG4-related disease. The patient is currently under observation on low-dose PLX4032 order oral prednisolone with no evidence of relapse. Conclusion: Our case demonstrates that IgG4-related disease is difficult to diagnose preoperatively and

needs a steroid therapy. IgG4-related disease in low rectum is an extremely rare case. Here we report a patient with IgG4-related disease of the low rectum. Key Word(s): 1. IgG4-related EPZ-6438 nmr disease; 2. rectum; 3. young patient Presenting Author: JAMES EMMANUEL Additional Authors: RUBEN RAJ, JAYARAM MENON, RAMAN MUTHUKARRUPAN, SULIONG CHIN, YE MYINT KHIN, OO THA NAING Corresponding Author: JAMES EMMANUEL Affiliations: Queen Elizabeth Hospital, Kota Kinabalu, Queen Elizabeth Hospital, Kota Kinabalu, Queen Elizabeth Hospital, Kota Kinabalu, Queen Elizabeth Hospital, Kota Kinabalu, University Malaysia Sabah, University Malaysia Sabah Objective: General objectives: 1. This study aims to identify the possible barriers to the implementation of the screening

programme such as public perception and awareness of the disease and importance of screening. 2. To make possible suggestions to overcome the barriers to implement a successful programme in the future. Specific objectives: 1. To determine the awareness of colorectal cancer and screening in the general population. To determine if the public is willing to partake in a screening programme if introduced. Methods: A random sample of 245 adults received a self administered questionnaire on socio-demographic characteristics, knowledge on colorectal cancer risk and screening tools, attitudes regarding perceived risk of developing CRC, utility

of screening test and source MCE of information. Results: Only 27.3% identified low physical activity (modifiable risk factor) as a risk factor for colorectal cancer. There was a significant difference on the level of knowledge of familial history of CRC as a risk factor for CRC between both genders whereby the male population was more aware of this. About half of the respondents identified colonoscopy as a screening tool. Those with a higher level of education were more knowledgable in identifying the accepted tools for CRC screening (FOBT/colonoscopy/barium enema). Two thirds of the respondents have not received any information of CRC in the past. Personal opinion that screening is useful in CRC prevention was high with a mean of 7.4. 82.8% of the respondents agreed that CRC may be treated when diagnosed at an early stage and 86.