The composites were evaluated for variation in their mechanical properties, rate of degradation, and interaction of the hydroxyapatite nanoparticles with the polymer chains. First, an ex vivo porcine model of cleft palate was used to determine the rate of cleft closure with applied force. The closure rate was found to be 0.505 mm N-1. From this approximation, the ideal maximum load was calculated to be 19.82 N, and the elastic modulus calculated to be 1.98 MPa. The addition of nHA strengthens POC, but also reduces the degradation time by 45%, for 3% nHA loading, compared to POC without nHA. X-ray diffraction data indicates
that the addition of nHA to amorphous POC results in the formation of a
semicrystalline phase of the POC adjacent to the nHA crystals. Based on the data, we conclude that amongst the 0-20% nHA loadings, a 3% loading of nHA in POC may be an ideal selleck kinase inhibitor material (1.21 MPa elastic modulus and 13.17 N maximum load) to induce contraction forces capable of facilitating osteogenesis and craniofacial bone repair. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 407-416, 2015.”
“Polynuclear zinc clusters [Znx] (x bigger than 2) with multicentred Zn-Zn bonds and +1 oxidation state zinc (that is, zinc(I) or Zn-I) are to our knowledge unknown check details in chemistry. Here we report the polyzinc compounds with an unusual cubic [Zn-8(I)(HL)(4)(L)(8)](12) (-) (L = tetrazole dianion) cluster core, composed of zinc(I) ions and short Zn-Zn bonds (2.2713(19) angstrom). The [Zn-8(I)]bearing compounds possess surprisingly high stability in air and solution. Quantum chemical studies reveal that the eight Zn 4s(1) electrons in the [Zn-8(I)] cluster fully occupy four bonding molecular orbitals and leave four antibonding ones entirely empty, leading
to an extensive electron delocalization over the cube and significant stabilization. The bonding pattern of the cube represents a class of aromatic system that we refer to as cubic aromaticity, which follows a 6n + 2 electron counting rule. Our finding extends the aromaticity concept to cubic metallic systems, and enriches Zn-Zn bonding chemistry.”
“Background: Detection of early pregnancy in the healthcare setting is important selleck chemicals for proper patient management. Qualitative point-of-care (POC) human chorionic gonadotropin (hCG) testing is often used. There is a gap in the literature for evaluating patient samples with low (<300 IU/I) hCG concentration using POC devices.\n\nMethods: Specimens (urine, n = 289; serum, n = 269) with hCG concentrations between 2 and >5000 IU/I were evaluated by hCG POC testing. Approximately half of these had an hCG concentration<300 IU/I. All specimens were evaluated using the OSOM and QuickVue+ POC hCG devices.