The EDIMCU is a windowless 9-bed unit that receives patients from multiple intra and inter-hospital origin, including from the ED, surgical and medical wards (as a step-up unit), ICU (as a step-down unit), recovery operatory room, and other hospitals (without intermediate and/or intensive care units). The criteria for admission to the EDIMCU follow the Guidelines

on Admission and Discharge for Adult Intermediate Care Units of the Society of Critical Medicine [18]. The unit provides non-invasive ventilation, invasive haemodynamic monitoring and Inhibitors,research,lifescience,medical inotrope infusion for high-risk medical and surgical patients; it does not provide renal replacement therapy or intracranial pressure monitoring. The standard nurse to patient ratio is 1:4 and a medical doctor is physically present in the unit (12-hour shifts). Patients and study design During a four-month Inhibitors,research,lifescience,medical period in April 2012 to July 2012, data was prospectively collected on all consecutive admissions Inhibitors,research,lifescience,medical to the EDIMCU (Hospital de Braga, Braga). Inclusion criteria included: patients aged 18 years or older admitted to the EDIMCU for more than 24hrs. Patients were excluded from the final analysis if the clinical staff was

unable to assess for delirium using the Confusion Assessment Method for the ICU (CAM-ICU) at any Inhibitors,research,lifescience,medical time during the admission, including due to clinical evaluation refusal by the patient, inability to follow simple commands before acute illness onset, language communication barriers, dementia

or other diagnosed neuropsychiatric disorder and coma. Exclusion criteria followed that reported in similar studies [9,19]. The delirium assessment analysis was completed for all patients who met the inclusion criteria (n = 283). Patients were followed at day 30 after hospital discharge (1-month follow-up); electronic charts were reviewed to ascertain the status of the patients, and when no up-to-date information Inhibitors,research,lifescience,medical was available patients or caregivers were contacted by telephone in an open-way interview. Outcomes were recorded as either “good” (recovery without complications tuclazepam requiring hospitalization or institutionalization) or “poor” (institutionalization in permanent care-units/assisted-living or death). For this observational study the Ethical Committee at Hospital de Braga approved the study protocol and waived informed consent. The study was non-interventional; therapies with regard to the clinical diagnosis, delirium and sedation state were left to the discretion of each patient’s attending physician. Data LEE011 cell line collection and study design Data were recorded prospectively at least once per 12-hour shift as part of the routine care, starting in the first 12 hours of admission to the EDIMCU.