The optimal timing of listing and transplantation of the HCV/HIV

The optimal timing of listing and transplantation of the HCV/HIV patient remains a challenge, and waiting list mortality appears higher than in HIV-negative patients [12]. Poor outcome might reflect late referral for transplant assessment and/or more rapid deterioration after the onset of hepatic decompensation. In either case, it is imperative that HIV-positive patients Trichostatin A purchase with a diagnosis of ESLD are co-managed by an experienced HIV physician and a hepatologist with close links to a transplant unit, thus permitting expeditious referral and assessment at the first sign of decompensation. 1 

Hepatitis B (chronic): Diagnosis and management of chronic hepatitis B in children, young people and adults. National Clinical Guideline Centre, 2013. Final draft for consultation. Available at (accessed May 2013). 2  Rosenthal E, Poiree M, Pradier C et al. Mortality due to hepatitis-C related liver disease in HIV-infected patients in France (Mortavic

2001 study). AIDS 2003; 17: 1803–1809. 3  Rosenthal E, Salmon-Céron D, Lewden C et al. for the Mortavic/Mortalité 2005 Study Group. Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19). HIV Med 2009; 10: 282–289. 4  Wandeler G, Gsponer T, Bregenzer A et al. for the Swiss HIV Cohort Study. Hepatitis C virus infections in the Swiss HIV Cohort Study: a rapidly click here evolving epidemic. Clin Infect Dis 2012; 55: 1408–1416. 5  Piroth L, Pol S, Lacombe K et al. Management and treatment of chronic hepatitis B virus infection in HIV positive and negative patients: the EPIB 2008 study. J Hepatol 2010; 53: 1006–1012. 6  Joshi D, O’Grady J, Dieterich

D, Gazzard B, Agarwal Cobimetinib solubility dmso K. Increasing burden of liver disease in patients with HIV infection. Lancet 2011; 377 (9772): 1198–1209. 7  Falade-Nwulia O, Seaberg EC, Rinaldo CR, Badri S, Witt M, Thio CL. Comparative risk of liver-related mortality from chronic hepatitis B versus chronic hepatitis C virus infection. Clin Infect Dis 2012; 55: 507–513. 8  Macias J, Berenguer J, Japon M et al. Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus. Hepatology 2009; 50: 1056–1063. 9  Merchante N, Giron-Gonzalez J, Gonzalez-Serrano M et al. Survival and prognostic factors of HIV-infected patients with HCV-related end stage liver disease. AIDS 2006; 20: 49–57. 10  Fierer DS, Dieterich DT, Fiel MI et al. Rapid progression to decompensated cirrhosis, liver transplant, and death in HIV-infected men after primary hepatitis C virus infection.

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