The postoperative course was not smooth on account of intractable UGI bleeding since 7th postoperative day. KPT-330 chemical structure So we recommended the continuously intravenous drip of somatostatin analogs in attempt to stop the bleeding but
in vain. Eventually the patient died of multiple-organ failures on 35th postoperative day. Results: We can not confirm Weather or not the postoperatively intractable GI hemorrhage is related to the residual (multifocal) NETs or GISTs because the further investigations including panendoscopy and endoscopic ultrasonography were not feasible for this critical case who needed respirator-support. But the 24-hr urine 5-HIAA was within normal range. Conclusion: This case presents the unique synchronous coexistence of two extremely rare GSK2126458 order entities, a low-graded GIST and a well-differentiated NET. Key Word(s): 1. Neuroendocrine tumor; 2. GIST; 3. PPU; Presenting Author: ALASDAIR PATRICK Additional Authors: JOHN HSAING Corresponding Author: ALASDAIR PATRICK Objective: To investigate the current prevalence of H. pylori infection in the patients of South Auckland Gastroenterology endoscopy service To estimate the antibiotics resistance pattern of H. pylori infection in South Auckland patients Methods: Consecutive patients undergoing gastroscopy
at Middlemore Hospital from February 2012, were recruited prospectively. All patients were checked to ensure they are treatment naïve (history, serology, previous endoscopy). All patients were consented for biopsy of stomach tissue for culture and antibiotics testing. Four antibiotics disc testing were performed (amoxicillin, tetracycline, clarithromycin, metronidazole and moxifloxacin). Within 24 hours, gastric biopsies of patients with positive CLO test (RUT) were send to the laboratory for culture and antibiotics testing. Results: 59 out of 351 patients enrolled were positive
for CLO test (rapid urease test RUT), giving a prevalence of 16.8% for treatment naïve patients in the population. The interim result of the 50 patients enrolled in the study, Y-27632 nmr 24% of the patients had GI bleeding, half of them with peptic ulcer disease. 22% had dyspepsia/abdominal pain, 22% had iron deificiency anaemia. Out of 50 samples positive for H. pylori, 34 samples were positive for culture. The antibiotics resistance for the five antibiotics were 5.9% (amoxicillin), 0.0% (tetracycline), 44.1% (metronidazole), 11.8% (clarithromycin), 8.8% (Moxifloxacin – assuming levofloxacin resistance level). The MIC50 and MIC90 listed in table below. Two out of 34 samples were resistant to both clarithromcyin and metronidazole. Two samples resistant to amoxicillin were also resistant to at least one other antibiotics (metronidazole (1), metronidazole and moxifloxacin (1)). Table 1 Amoxycillin Tetracycline Metronidazole Clarithromcyin Moxifloxacin Culture positive 34 34 34 34 24 MIC 50 0.016 0.016 0.125 0.016 0.0395 MIC90 0.06 0.094 >256 24 0.