Therefore, the use of the CVS task or the normative data in unhea

Therefore, the use of the CVS task or the normative data in unhealthy populations is not supported by the findings of this study alone. Conclusion In this study, we quantitatively analyzed the functional brain properties of a CVS task. The task was found to provide robust activation of the occipital lobe, as well as regions in the middle frontal gyrus associated with coordinating eye movements and in regions of the insula associated with task-level control and focal attention. As expected, the task demonstrated deactivation patterns commonly implicated in the default-mode network. Further deactivation was noted in the posterior region of the cerebellum, most likely associated

Inhibitors,research,lifescience,medical with the formation of optimal search strategy. We believe the task will be useful in studies of visual attention in the neuroscience community as well as in mapping visual function in

clinical fMRI. Acknowledgments We would like to thank Raymond Poelstra, MD, and Marilyn Reed, BSN, for their helpful discussions and input in the design and implementation Inhibitors,research,lifescience,medical of the CVS for presurgical treatment planning. We thank Lynn Caldwell, PhD, Regina Schmidt, PhD, Laurie Quill, MS, Nicole Arbuckle, MS, and Kristie Nemeth, MS, for helpful discussions and input in the design and implementation of the CVS Inhibitors,research,lifescience,medical with regard to the study of human performance. We acknowledge funding support from the US Air Force during the development of the CVS. Conflict of Interest None declared. Funding Information We acknowledge funding support from the US Air Force during the development of the CVS.
Please note that an editorial related to this article, “The role of FGF2 in spinal cord trauma and regeneration research,” doi: 10.1002/brb3.207, can be Inhibitors,research,lifescience,medical found here, also published

in Brain and Behavior. Introduction In mammals, a major barrier for axonal regeneration Inhibitors,research,lifescience,medical after spinal cord injury (SCI) is the formation of the glial scar at the lesion. The glial scar is composed of astrocytes, which are triggered in response to extrinsic DNA Damage inhibitor signals to activate and proliferate to generate a dense network of hypertrophic stellate cells that form an impenetrable barrier to the regrowth of damaged axons. Thus, one therapeutic strategy could be to improve the environmental conditions at the lesion site post-SCI to better support neuronal survival and axonal regrowth. Neurotrophic factors are good candidates to be examined due to their supportive MTMR9 role during developmental neurogenesis. In addition to improving environmental signals, therapies need to target the cells that are already present at the injury site as these can play crucial roles in either supporting or blocking regeneration. For example, induction of radial glia-like and neuronal progenitor cells, which during development serve as scaffolds to support neuronal migration and give rise to neurons, may improve regeneration.

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