They play a considerable part in the development of several neoplastic diseases and illnesses from the connective tissues. Two in the most significant enzymes from this group are matrix metalloproteinase two MMP two and matrix metalloproteinase 9, whose substrates are collagens type I, IV, V, VII, X, XI, XIV, gelatine, fibronectin, laminin, agrecan, and casein. Because of the diversity in the substances af fected by this enzyme, its activity level is accountable for the course of quite a few pathological processes in humans. The substances that hamper angiogenesis are tissue inhibitors of metalloproteinases. TIMPs com prise the family of four proteins, multifunctional com pounds which, regardless of their inhibiting influence on MMPs, play a substantial function in keeping a balance involving synthesis and ECM proteins in several physiological and pathological processes.
TIMP 1 and TIMP 2 are extremely particular to MMP 2 and MMP 9. In the selleckchem literature there are few reports on the concen tration values of metalloproteinases and their tissue inhibitors in serum on the pancreatic tumor patients. Similarly, not many reports describe the concen tration of these enzymes and their inhibitors due to the advanced stage of a pancreatic tumor. The aim of the study was to evaluate the concentra tion of proteolytic enzymes MMP two and MMP 9, and their tissue inhibitors TIMP 1 and TIMP 2 inside the blood of sufferers with benign and malignant pancreatic tumors, also as providing answers towards the following concerns, a. Can any changes in concentration in the studied variables in blood be observed b.
Can the concentration of these elements in blood be treated as a preoperative differential parameter for benign and malignant pancreatic tumors c. Does the concentration of MMPs and TIMPs in blood correlate with one another too as together with the clinical severity of a pancreatic tumor d. Does the removal of a pancreatic tumor affect the concentration modify of those variables informative post Can a probable difference in concentrations have an influence around the prognosis of a pancreatic tumor Techniques The study was conducted on 134 Caucasian patients aged 54 to 76 years with pancreatic tumors, who underwent surgical therapy within the Division of Thoracic Surgery, Common and Oncological Surgery, Health-related University of Lodz, involving the years 20072011. Every single studied patient was subject to pancreatic and biliary surgery.
The studied individuals had been divided into 4 groups de pending around the type of tumor, which was classified via the TNM system just before and just after surgery around the basis with the perioperative picture, the range of surgery, and follow up inside 1 to two years soon after the process, 1. Group I, individuals with pancreatic cancer at advanced stages I and II of severity on the day in the operation, no recurrence or metastases to distant organs inside 2 years following surgery, 2.