A 53-year-old woman was admitted to Leningrad Regional Clinical Hospital in September 2010. She was in severe condition, conscious but retarded. She had general weakness and exertional

dyspnoea. The body temperature was 38.7 °C. Auscultation revealed vesicular breathing diminished bilaterally selleck chemicals in the lower parts of lungs. Respiration rate was 20–30 per minute. Blood pressure was 110/70 mm Hg, heart rate 99 per minute. On the left chest area, an unhealed postoperative wound was apparent. Patient’s medical history revealed that a tumour of the left breast was detected in June 2010. On August 10, 2010 Madden modified radical mastectomy of the left breast was performed. The examination revealed leucopoenia (2.2 × 109/l), thrombocytopenia

this website (89 × 109/l) and anaemia (Hb 97 g l−1). Body temperature was above 38 °C during hospitalisation. In the hospital, blood tests showed pancytopenia (RBC 2.6 × 1012/l, Hb 70 g l−1, WBC 2.5 × 109/l, blasts 15%, promyelocytes 1%, neutrophils 6%, basophils 2%, lymphocytes 75%, monocytes 1%, PLT 11 × 109/l). Immunophenotyping of the bone marrow revealed the transformed cells with intermediate and high level of granularity with the total immunophenotype CD45dim CD117+ CD33+ CD38+ MPO+. The absence of antigens CD34, HLA-DR, CD7 and high level of cells granularity was regarded. The diagnosis based on the survey was AML, condition after Madden radical left-side mastectomy (August, Ergoloid 2010). On September 30, 2010 cytostatic chemotherapy ‘7 + 3’ (cytarabine + idarubicin) was started. During the chemotherapy febrile neutropenia appeared and antibiotics (cefepime, ciprofloxacin, metronidazole, and imipenem) were used. Fever above 38 °C persisted. On chest CT scan (October 6, 2010) were found local infiltration in S2 of the right lung, focal lesion in S9 of the left lung and right-sided pleural effusion. On October 13, patient had developed intense pain in the postoperative wound. The necrotic area of soft tissue 2 cm in diameter was detected. Vancomycin was added to the therapy. The

next day the pain increased, the necrotic area enlarged to 10 cm in diameter, body temperature went above 38 °C. The material from postoperative wound area was obtained for mycological examinations. On microscopy non-septate non-pigmented hyphae were found. On October 16, abundant growth of moulds was received. The culture was identified as Lichtheimia corymbifera. Mucormycosis of skin and soft tissue of postoperative wound was diagnosed. Therapy with amphotericin B was started with a dose 1 mg kg−1 d−1 (7 days), than 1.5 mg kg−1 d−1, and G-CSF (leykostim) 480 mcg d−1 was used. Chest CT scan (October 18) showed infiltrate 1 × 1.4 × 2.1 cm in S2 of the right lung, fluid in the pleural cavity, focal lesion 0.44 cm in S9 of the left lung, non-homogenous infiltration 2.0 × 1.9 cm on the II-V intercostal level on the frontal and left-side lateral surface (Fig. 1).