Clinical physiological parameters such as age,

gender, BMI, body temperature, pulse rate, and blood pressure were evaluated, as well as routine laboratory data obtained on admission. Routine laboratory data included a complete blood cell count (CBC), hepatobiliary enzyme levels, renal function and blood sugar (BS) levels. The enrolled patients were subjected to subgroup analysis and categorized into three groups: (i) normal ALT defined as find more a serum ALT level of <42 IU/L, (ii) moderately elevated ALT defined as a serum ALT level between 42 IU/L and <840 IU/L (20 times above the institutional upper normal limit), and (iii) highly elevated ALT defined as a serum ALT level of >840 IU/L. The above three subgroups were evaluated statistically by analysis of variance (anova). If a significant difference was found, multiple comparisons (post hoc test) were performed with Tukey–Kramer and Steel–Dwass test. The risk related to elevated ALT was analyzed by univariate and multivariate logistic regression.

The results INK 128 purchase of logistic regression analysis were expressed as odds ratio with 95% confidence interval. Differences after these modifications were considered significant at P < 0.05. Analyses were performed by using Excel Statistics (2010, Social Survey Research Information, Tokyo, Japan). The backgrounds of the 37 enrolled patients are listed in Table 1. The ages of the patients ranged from 12 to 67 years (median age 24 years), and all MCE公司 were lean females with a mean BMI on admission of 13 kg/m2. The serum ALT level ranged widely from 11

to 2321 IU/L, with a median of 27 IU/L. Besides liver injury, physiological and laboratory abnormalities frequently associated with AN, such as bradycardia, hypothermia, hypotension, anemia, leukopenia, thrombocytopenia, hyponatremia, hypokalemia, and hypoglycemia were present in some of the enrolled patients. Elevated liver enzyme (serum ALT level ≥42 IU/L) was observed in 13 (35%) of the 37 cases. Highly elevated ALT was evident in four cases (11%), the median ALT level being 1986.5 IU/L. Patients in the moderately elevated ALT group accounted for 24% of the subjects overall (9/37), and the median ALT level was 71 IU/L. The median serum ALT level in the normal ALT group was 20.5 IU/L. The clinical parameters in these three groups are detailed in Table 2. Among the clinical parameters evaluated, body temperature, pulse rate, blood urea nitrogen (BUN), BUN/creatinine ratio, BS, and platelet count differed significantly among the groups (P < 0.05). These six parameters were further analyzed statistically, and this revealed that both BUN and the BUN/creatinine ratio were significantly higher in the high ALT group than in the normal ALT (P < 0.05) and moderate ALT (P < 0.05) groups, respectively (Fig. 1). Body temperature, BS and platelet count were significantly lower in the high ALT group than in the normal ALT (P < 0.05) and moderate ALT (P < 0.05) groups.