perfrigens, Staph aureus, Staph epidermidis Pain, fever, swelling, crepitus Pip/Taz, Clind, Vanc → Meropenem/Skin grafting Septic shock, myoglo-binuria, RF/120d/limited function 54/M [10] DM, cecal cancer Arm/C septicum ATM Kinase Inhibitor supplier 24 hr arm/abdominal pain, fever, nausea, vomiting, diarrhea, shoulder tenderness, induration, crepitus Pip/Taz, Clind, Vanc Anemia/NR/NR 37/M [5] Posttraumatic

Head fracture Shoulder/C perfrigens S epidermidis shoulder pain, fever, agitation, crepitus Vanc → Pen/Clind/Metr → Cefo, Metro → Pen/Metro → Metro p.os Anosmia/40d/Normal 26/M [9] Intravenous drug user Lower limb/C perfringens, Beta- Streptococci, enterococci Suspected DVT, thigh/left iliac Gilteritinib mw fossa tenderness Pen, Clind, Metr/femoral artery vascular grafting Femoral vein, artery and nerve erosion/126d/Mobile 49/M [23] VX-765 Postoperative Hand/C perfrigens C sordellii 1st postoperative day pain/fever Pen -/21d/normal 55/M [12] DM, peripheral vascular disease, cecal mass Hip/C septicum Pain, fever, crepitus Pip/Taz, Clind, Ceft→Pip/Taz, Clind RF, myoglobinuria/NR/NR 58/M [6] Posttraumatic Heel/ Foot pain, fever, Antibiotics, hyperbaric oxygen, Skin grafting MOFS/78d/normal 32/M [11] Postoperative Lower limb/C septicum Pain, crepitus NR NR/NR/NR

83/M [14] Sciatica, pneumonia, colon cancer Hip, thigh/C septicum 3 days, hip pain, fever, nausea, vomiting Vanc, Genta, Imip/Sil → Am/Cl/Right hemicolectomy

-/16d/ambulated with assistance 47/M [4] chronic pancreatitis, DM, pentazocin injection sites. Thigh – buttock/C perfrigens 6 day pain, swelling, fever, Pen, Metr, polyvalent clostridial antitoxin,/Skin grafting Respiratory failure,/NR/normal 25/M [7] Crush injury Leg/C perfrigens Pain, fever, limb discoloration, edema, crepitus Cefalotin → Pen, hyperbaric oxygen/skin-bone grafting -/180d/able to bare weight 48/F [24] Posttraumatic Knee/C perfrigens Pain, stiffness, tenderness Terra → Pen, Gas gangrene serum -/21d/normal Pip/Taz: piperacillin/tazobactam, Clind: selleck products clindamycin, Vanc: vancomycin, Pen: penicillin G, Metr: metronidazole, Genta: gentamycin, Imip: imipenem, Sil: silastatin, Am/Clav: amoxicillin/clavulate, Terra: terramycin, DM: diabetes mellitus, UC: ulcerative colitis, DVT: deep venous thrombosis MOFS: multiorgan failure RF: renal failure NR: not reported. All patients underwent wide surgical debridement of the affected area and were administered antimicrobial treatment. Three out of eleven patients underwent at least a second wound debridement after initial operation [5–7]. A detailed list of antimicrobial regimens used in these patients is presented in Table 1. Penicillins, clindamycin or metronidazole were included in the initial antibiotic regimen in 70% of cases.