Results: The ceramic vessel gave a sufficient yield of Zr-89 (57 +/- 11 MBq/pAh), showed good operability, and could be reused up to 10 times. With nominal irradiation (10 mu A x 2 h) in similar to 90 mu L, the product (similar to 940 MBq) was obtained with >99.9% radionuclidic purity.

Conclusion: The combination of the ceramic vessel and vertical irradiation has great potential

for the remote production of various metallic radionuclides. (C) 2012 Elsevier Inc. All rights reserved.”
“Objective: Invasive mediastinal biopsy is often necessary in the evaluation of non-small cell lung cancer (NSCLC), and mediastinoscopy has long been considered the reference standard. However, the emergence of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has resulted in controversy regarding it represents a suitable replacement for mediastinoscopy. We chose to determine the utility of EBUS-TBNA in evaluating the mediastinum selleck screening library in patients with NSCLC.

Methods: The present study was a retrospective review of a prospective database of consecutive patients with NSCLC who underwent

EBUS-TBNA for mediastinal evaluation CFTRinh-172 ic50 from 2009 to 2011. The sensitivity, specificity, negative predictive value, and accuracy of EBUS-TBNA are reported. Also reported are the size of the lymph nodes biopsied and the number of instances in which EBUS-TBNA obviated the need for cervical mediastinoscopy.

Results: A total of 73 patients had a total of 140 mediastinal stations biopsied using EBUS-TBNA. Of the 73 patients, 30 had benign findings and underwent surgical resection, 1 of whom was found to have stage N2 disease. Of the remaining patients, 42 had a positive result Methocarbamol and 1 had nondiagnostic biopsy findings for which malignancy was confirmed by mediastinoscopy. Mediastinoscopy would have changed the tumor stage and treatment planning in only 2 (2.7%) of the 73 patients. Overall, EBUS-TBNA had a sensitivity of 95%, a specificity

of 100%, a negative predictive value of 94%, and an accuracy of 97%.

Conclusions: EBUS-TBNA might be a feasible option for most patients with NSCLC for whom histologic assessment of the mediastinum is necessary. The rates of nondiagnostic and false-negative biopsy findings using EBUS-TBNA were low, small subcentimeter nodes could be routinely biopsied, and most patients with a radio-graphically positive mediastinum had their disease pathologically confirmed. (J Thorac Cardiovasc Surg 2012;143:585-90)”
“Chronic circadian desynchronization induced by repeated 12 h light-dark cycle shifts conducted twice weekly resulted in elevated food intake, body weight gain, and retroperitoneal fat mass in male F344 rats. Using a proteomic approach, we found that repeated light-dark shifts caused changes in expression levels of five hypothalamic (four upregulated) and 22 retroperitoneal fat (13 upregulated) 2-DE protein spots.