The GTE and ethyl acetate fractions exhibited strong growth inhibitory activity against P. mirabilis and S. pyogenes, whereas the aqueous fraction possessed poor antimicrobial activity. Among the catechins, epigallocatechin gallate showed strong antibacterial activity. C. albicans was potently inhibited by the methylene chloride fraction and caffeine, while antifungal activity of GTE was contributed by caffeine. Furthermore, we evaluated whether in vitro activity of GTE included purified solvent fractions that were Navitoclax inhibitor stable to heat and pH. Antimicrobial
activity was potent in alkaline environment for P. mirabilis and acid environment for S. pyogenes and C. albicans. Herein GTE can be a valuable
therapeutic agent for the treatment of vaginal-related pathogens.”
“PURPOSE: To evaluate HM781-36B changes in corneal curvature, corneal elevation, corneal thickness, lens density, and foveal thickness after corneal collagen crosslinking with riboflavin and ultraviolet-A (UVA) light in eyes with progressive keratoconus.
SETTING: Grewal Eye Institute, Chandigarh, India.
METHODS: Subjective refraction, best corrected visual acuity (BCVA), Scheimpflug imaging, and optical coherence tomography were performed preoperatively and 1 week, 1, 3, and 6 months, and 1 year after crosslinking.
RESULTS: There were no significant differences (P > 0.05) in mean values between preoperatively
and 1 year postoperatively, respectively, in BCVA (0.22 +/- 0.10 and 0.20 +/- 0.10), spherical equivalent (-6.30 +/- 4.50 diopters (D) and -4.90 +/- 3.50 D), Cilengitide or cylinder vector (1.58 x 7 +/- 3.8 D and 1.41 x 24 +/- 3.5 D). There was no significant difference in mean measurements between preoperatively and 1 year postoperatively, respectively, for central corneal thickness (458.9 +/- 40 mu m and 455.2 +/- 48.6 mu m), anterior corneal curvature (50.6 +/- 7.4 D and 51.5 +/- 3.6 D), posterior corneal curvature (-7.7 +/- 1.2 D and -7.4 +/- 1.1 D), apex anterior (P = .9), posterior corneal elevation (P = .7), lens density (P = .33), or foveal thickness (175.7 +/- 35.6 mu m and 146.4 +/- 8.5 mu m; P = .1).
CONCLUSIONS: Stable BCVA, spherical equivalent, anterior and posterior corneal curvatures, and corneal elevation 1 year after crosslinking indicate that keratoconus did not progress. Unchanged lens density and foveal thickness suggest that the lens and macula were not affected after UVA exposure during crosslinking.”
“The slippability of packaging films has to be controlled to facilitate confectionary operations and guarantee an easy opening for filling.