This study is to explore the endoscopic and clinical feature of esophageal IMT. Methods: To study Ipilimumab in vitro the endoscopic and clinical features of esophageal inflammatory myofibroblastic tumors (IMT) retrospectively by 2 cases of IMT confirmed by pathological results. Both of patients presented with food impaction. Gastroscopy and endoscopic ultrasound(EUS) were used to detect the esophageal submucosal mass on these 2 patients before surgery. The 2 masses were successfully removed and the diagnosis of IMT was confirmed by pathological results. Results: Esophageal protrusions with narrowed lumen were revealed by gastroscopy. The covering mucosa appeared

to be ulcerative or nodular. In EUS, the layers of esophageal wall can not be clearly identified and presented with heterogeneous mass. The mass appeared to have capsule. In one case, the capsuled was protruded indicating malignance but obviously different from esophageal carcinoma. In addition, IMT has some submucosal features in EUS but apparently different from other common submucosal tumors such as leiomyoma and GIST.

In pathology, there was a dense population of fibroblastic cells with some inflammatory cells including plasma cells, lymphocytes and eosinophils. www.selleckchem.com/products/EX-527.html The fibroblastic cells extended through the muscular layer to the adventitia. With immunohistochemistry stains, spindle cells were positive for vimentin and diffusely positive for anaplastic lymphoma kinase, SMA and desmin, negative for S-100, CD34 and CD68. Conclusion: Food impaction might be the most common symptom of esophageal IMT. Gastroscopy and EUS has predict value in diagnosis of IMT. The pathology and immunohistochemistry are conclusive for the definite diagnosis. Key Word(s): 1. IMT; 2. endoscopy; 3. EUS; 4. pathology; Presenting Author:

WU SHUANG Additional Authors: LI YUQIN, WANG LIBO, TANG TONGYU, 上海皓元 XU HONG Corresponding Author: WU SHUANG Affiliations: Department of Gastroenterology of 1st Hospital of Jilin University Objective: Colonoscopy is widely used for detection of colorectal neoplasia. However, the rates of detection of neoplasia vary among endoscopists with different withdrawal time. This study was conducted to investigate correlation of the rate of detection and the time taken to withdraw the colonoscope. Methods: Patients(aged from 40 to 60) who underwent colonoscopies from April, 2011 to April 2013 were enrolled. Endoscopists of similar seniority were involved and the same endoscopic device (OLYMPUS EVIS LUCERA 260) were used to all patients. According to previous recommendation, 6 minutes is the minimum length of time to allow adequate inspection.