XRD, SEM, IR and TEM were employed to investigate the effect of recombinant human-like collagen on the formation of hydroxyapatite. The results showed that nano-hydroxyapatite coating could
be formed on pretreated NiTi alloy in CSBF (Collagen Simulated Body Fluid), and the coprecipitation of hydroxyapatite and recombinant human-like collagen were confirmed by IR CFTR inhibitor spectrum with the typical peaks of phosphate and amide bands. Moreover, hydroxyapatite nanocrystals showed preferential orientation oil collagen fibrils with the c-axis of hydroxyapatite being parallel to the longitudinal direction of the collagen fibrils. The nano-hydroxyapatite coating with special structure would benefit for the application of NiTi alloy in the orthopaedic field. (C) 2008 Elsevier B.V. All rights reserved.”
“Stress and hypercaloric food are recognized
risk factors for obesity, Metabolic Syndrome (MetS) and Type 2 Diabetes (T2D). Given the complexity of these metabolic processes and the unavailability of animal models, there is poor buy AZD7762 understanding of their underlying mechanisms. We established a model of chronic psychosocial stress in which subordinate mice are vulnerable to weight gain while dominant mice are resilient. Subordinate mice fed a standard diet showed marked hyperphagia, high leptin, low adiponectin, and dyslipidemia. Despite these molecular signatures of MetS and T2D, subordinate mice fed a standard diet were still euglycemic. We hypothesized that stress predisposes
subordinate mice to develop T2D when synergizing with other risk factors. High fat diet aggravated dyslipidemia and the MetS thus causing a pre-diabetes-like state in subordinate mice. Contrary to subordinates, dominant mice were fully protected from stress-induced metabolic disorders when fed both a standard- and a high fat-diet. Dorsomorphin in vitro Dominant mice showed a hyperphagic response that was similar to subordinate but, unlike subordinates, showed a significant increase in VO2, VCO2, and respiratory exchange ratio when compared to control mice. Overall, we demonstrated a robust stress- and social status-dependent effect on the development of MetS and T2D and provided insights on the physiological mechanisms. Our results are reminiscent of the effect of the individual socioeconomic status on human health and provide an animal model to study the underlying molecular mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.”
“Sudden cardiac death in the young (SCDY) is the leading cause of death in young athletes during sport. Screening young athletes for high-risk cardiac defects is controversial. The purpose of this study was to assess the utility and feasibility of a comprehensive cardiac screening protocol in an adolescent population. Adolescent athletes were recruited from local schools and/or sports teams.