(C) 2010 Elsevier Ltd. All rights reserved.”
“A high-performance of uniaxial alignment of electrospun nanofibers was realized by introducing an inclined gap into dual collectors that consisted of two conductive strips. Because the two strips that were configured horizontally and vertically had a height difference from the inclined gap, the electrospun nanofibers were

sequentially suspended across the edges of strips in a well-aligned and regularly distributed form. Some parameters, such as concentration of solution, applied voltage, and spinning distance were considered for the successful suspension and formation of the aligned electrospun fibers. The method could improve the properties of nanofiber alignment and allow for easy selleck chemicals transfer onto other solid substrates or devices. The alignment technique used polycaprolactone, which resulted in continuous and well-aligned nanofibers with diameters ranging from 500 to 700 nm. Furthermore, it is suggested that repetitive transfer be used to SB273005 achieve a higher density of aligned nanofiber arrays. This would enlarge the applicability

of nanofibers, especially for the tissue engineering field. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 1800-1807, 2011″
“Deja vu aura is a well-known phenomenon experienced by some patients with epilepsy. This study sought to explore the relationship between verbal memory and the experience of deja vu or other types of mnemestic auras in 42 individuals with intractable seizures and 42 age- and education-matched patient controls. Verbal memory was assessed with indices of learning, long delay recall, and recognition from the California Verbal Learning Test. Entinostat purchase Results indicated that auras of any type were not associated with memory performance on the California Verbal Learning Test. As expected, age and education were related to verbal memory performance. Mnemestic auras were associated with clinical indices of illness, suggesting that the presence of these auras may be regarded as a risk factor for greater chronicity and severity in epilepsy.

(C) 2010 Elsevier Inc. All rights reserved.”
“The effects of heat treatment on the survival of isolated Ephestia kuehniella Zeller larvae were examined. Larvae were treated in a specific device at a temperature range of 46 to 70 degrees C. Statistical analysis of the data demonstrated that the thermal survival kinetics was best represented by a 2-parameter Weibull model above 50 degrees C. The mortality of larvae only occurs beyond a critical temperature of 41.6 degrees C +/- 2.5 degrees C. A 20 axial-symmetric model of heat transfer (convection, microwave at 915 MHz) was developed for cocoa bean and date palm. It was combined with the survival rate of larvae (Weibull model) and some z-values (from literature) are used for calculating a “”food quality index”" degradation kinetics.

Therefore, it is recommended that a protective barrier be used over the canal filling to prevent leakage of bleaching agents. Glass-ionomer (GI) is commonly used as a coronal barrier before nonvital bleaching. Because mineral trioxide aggregate

(MTA) creates high alkalinity after mixing with water, using MTA as a protective GW3965 cell line barrier over the canal filling may not only prevent leakage of bleaching agents and microorganisms, but may prevent cervical resorption. The aim of this study was to evaluate sealing ability of white mineral trioxide aggregate (WMTA) as a coronal barrier before nonvital bleaching.

Study design: Root canals of one hundred thirty human maxillary incisors were instrumented and filled with gutta-percha without sealer. Gutta-percha was removed up to 3 mm below the cementoenamel junction (CEJ). The teeth were randomly divided into six experimental groups of 20 teeth each and two control groups of 5. In three experimental groups, WMTA was packed into the canal to the level Z-IETD-FMK nmr of CEJ. In the remaining experimental groups, glass-ionomer (GI) was used as a coronal barrier. After a 24-hour incubation period, one of the following three bleaching agents was placed in the access cavity of each of the WMTA or GI groups. These three

bleaching agents were 30% hydrogen peroxide, sodium perborate mixed with 30% hydrogen peroxide, and sodium perborate mixed with distilled water. The bleaching agents were replaced every 3 days for three times. In the positive controls,

no coronal barrier was used. In the negative controls, all the tooth surfaces were covered by two layers of nail varnish. Microleakage was evaluated using protein leakage test. Statistical analyses were performed with the Kruskal-Wallis and Mann-Whitney tests.

Results: The experimental groups showed minimum leakage which was not significantly more than tha in the negative controls. There was no statistically significant difference in leakage Wnt activity between the experimental groups (p<0.05).

Conclusions: This study indicated that different bleaching agents have no effect on sealing ability of WMTA.”
“An 8-year-old boy developed a large aneurysm of the aortic arch after neonatal complete repair of interrupted aortic arch type B and closure of a perimembranous ventricular septal defect. To our knowledge, this unusual complication has not been previously reported in the English literature.”
“In 2011, the Division of Violence Prevention (DVP) within CDC’s Injury Center engaged an external panel of experts to review and evaluate its research and programmatic portfolio for sexual violence (SV) prevention from 2000 to 2010. This article summarizes findings from the review by highlighting DVP’s key activities and accomplishments during this period and identifying remaining gaps in the field and future directions for SV prevention.

When the effective electron mass is much smaller than that of holes, the thermalization of holes has little influence on lowering the conversion efficiency. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3086447]“
“Objective. The objective of this project was to develop core competencies in pain assessment and management for prelicensure health professional education.

Such core pain competencies common to all prelicensure health professionals have not been previously reported.

Methods. An interprofessional executive committee led a consensus-building process to develop the core competencies. An in-depth literature review PF-6463922 chemical structure was conducted followed by engagement of an interprofessional Competency Advisory Committee to critique competencies through an iterative process. A 2-day summit was held so that consensus could be reached.

Results.

The consensus-derived competencies were categorized within four domains: multidimensional nature of pain, pain assessment and measurement, management of pain, and context of pain management. These domains address the fundamental concepts and complexity of pain; how pain is observed and assessed; collaborative approaches to treatment options; and application of competencies across the life span in the context of various settings, Tariquidar price populations, and care team models. A set of values and guiding principles are embedded within each domain.

Conclusions. These competencies can

serve as a foundation for developing, defining, and revising curricula and as a resource for the creation of learning activities VE-821 manufacturer across health professions designed to advance care that effectively responds to pain.”
“Effects of alpha-, gamma-, and delta-tocopherols at 0, 50, 100, 250, 500, and 1,000 ppm on the oxidative stability of lard during storage in the dark at 55A degrees C for 7 days were studied by determining headspace oxygen content and peroxide value. The headspace oxygen content of the lard without tocopherol addition decreased from 21.1 to 14.4% and the peroxide value increased from 2.5 to 15.4 meq/kg lard for 7 days. The headspace oxygen depletion and the peroxide value of lard decreased by the addition of alpha-tocopherol at 50 ppm, but significantly increased at 250, 500, or 1,000 ppm. As the concentration of gamma-tocopherol or delta-tocopherol increased, the headspace oxygen depletion and the peroxide value decreased. alpha-Tocopherol at 250 ppm acted as a prooxidant in the autoxidation of lard. The concentrations of gamma- or delta-tocopherol to be applied to improve the autoxidative stability of lard may be 100-250 ppm.”
“We investigated the exchange-coupling fields of CoFe/Ru (t(Ru))/CoFe synthetic antiferromagnetic (SyAF) structures with a Ru underlayer and capping layer before and after annealing at 300 and 350 degrees C.

“
“OBJECTIVE: Infection and inflammation play a role in carcinogenesis, and highly prevalent oral and dental diseases have been significantly linked to some types

of cancer. This article reviews current literature in this area.

MATERIALS AND METHODS: AZD7762 supplier Open literature review using the PubMed database and focused on publications from 2000 to 2010.

RESULTS: Numerous potential mechanisms are implicated in the oral disease/carcinogenesis paradigm, including infection-and inflammation-associated cell pathology and microbial carcinogen metabolism. Poor oral hygiene is associated with oral cancer, but there is also evidence of a possible link between oral or dental infections and malignancies in general.

CONCLUSION: Oral infections may trigger malignant transformation in tissues of the mouth and other organs. However, scientific evidence to date remains weak and further well-conducted studies are warranted before cancer can be properly added to the list of oral infection-related systemic diseases. Oral Diseases (2011) 17, 779-784″
“Weight loss issues are one of the problems that can affect patients after undergoing bariatric surgery. We report the

feasibility, safety and preliminary outcomes of laparoscopic conversion of Roux-en-Y gastric bypass (RYGB) to sleeve gastrectomy (SG), as a first step of duodenal switch (DS), for insufficient weight loss or weight regain.

Between August 2007 and November 2009, four patients benefited from laparoscopic conversion for insufficient weight loss or weight regain, mainly due Vactosertib to a new dietary behaviour such as sweet eating. At the time of RYGB, the mean weight and body mass index (BMI) was 118.5 +/- 32.8 kg and

43.2 +/- 8 kg/m(2), respectively. The mean interval time between RYGB and conversion to SG was 36.7 +/- 15.6 months. At the time of conversion, the mean weight, BMI, % excess weight loss (%EWL) and % excess BMI loss (%EBMIL) was 101.7 +/- 24.7 kg, 37.3 +/- 6.6 kg/m(2), 27.5 +/- 11.8% and 26.5 +/- 12%, respectively. The procedure involved the dismantling of both anastomosis, performance of SG before restoration of gastric continuity, and new small check details bowel anastomosis.

Mean operative time was 233.7 +/- 46.4 min. There were no conversions to open surgery and no mortality. One patient developed a gastric fistula. Mean hospital stay was 20.2 +/- 17.9 days. After a mean follow-up of 11 +/- 12.8 months, the mean weight, BMI, %EWL and %EBMIL was 81 +/- 12.1 kg, 30.3 +/- 5.1 kg/m(2), 59.3 +/- 31.5% and 42.3 +/- 34.5%, respectively. During follow-up, one patient underwent the second step of DS.

Laparoscopic conversion of RYGB to SG is feasible and safe despite the development of gastric fistula. Weight loss is increased, leaving the patients in better conditions to undergo the second step of DS.

“
“Background: The increasing number of multidrug-resistant

Plasmodium strains warrants exploration of new anti-malarials. Medicinal plant research has become more important, particularly after the development of Chinese antimalarial drug artemisnin from Artemisia annua. The present study shows evaluation of anti-malarial effects of two plants commonly used against malaria in the Garhwal region LBH589 clinical trial of north-west Himalaya, in order to discover the herbal-based medicine.

Methods: In vitro anti-plasmodial sensitivity of plant extracts was assessed using schizont maturation and parasite lactate dehydrogenase (pLDH) assay. Cytotoxic activities of the examined extracts were determined on L-6 INCB024360 research buy cells of rat skeletal muscle myoblast. The 4-day test for anti-malarial activity against a chloroquine sensitive

Plasmodium berghei NK65 strain in Swiss albino mice was used for monitoring in vivo activity of plant extracts.

Results: Chloroform extract of H. antidysenterica (HA-2) and petroleum ether extract of V. canescens (VC-1) plants significantly reduced parasitaemia in P. berghei infected mice. The extract HA-2 showed in vitro anti-plasmodial activity with its IC(50) value 5.5 mu g/ml using pLDH assay and ED(50) value 18.29 mg/kg in P. berghei infected Swiss albino mice. Similarly petroleum ether extract of V. canescens (VC-1) showed in vitro anti-plasmodial activity with its IC(50) value 2.76 mu g/ml using pLDH assay and ED(50) 15.8 mg/kg in P. berghei infected mice. The extracts coded as HA-2 at 30 mg/kg and VC-1 at 20 mg/kg exhibited parasite inhibition in mice: 73.2% and 63.0% respectively. Of these two plant extracts, petroleum ether extract of V. canescens was found slightly cytotoxic.

Conclusion: The present investigation reflects the use of these traditional medicinal plants against malaria and these plants may work as potential source in the development of variety of herbal formulations for the treatment

of malaria.”
“The melt blending of polylactide (PLA) and thermoplastic polyurethane (TPU) elastomer was performed in an effort to toughen the PLA. The phase morphology, mechanical properties, and toughening mechanism ABT-263 of the PLA/TPU blends were investigated. The results indicate that the spherical TPU particles dispersed in the PLA matrix, and the uniformity decreased with increasing TPU content. There existed long threads among some TPU droplets in blend with 30 wt % TPU. TPU improved the toughness of the PLA. With 30 wt % TPU, the elongation at break of the blend reached 602.5%, and samples could not be broken in the notched Izod impact tests at room temperature. The matrix ligament thickness of the PLA/TPU blends was below the critical value, and the blends deformed to a large extent because of shear yield caused by debonding, the formation of fibers upon impact; this dissipated a large amount of energy. (C) 2011 Wiley Periodicals, Inc.

The criterion-related validity of OHIP-49T was evaluated through associations between the OHIP-49 score with prosthetic need and prosthetic check details status. A subset (OHIP-14T) questionnaire, derived through a controlled regression procedure,

was compared with the original OHIP-14 by Slade (OHIP-14S).

The Cronbach’s alpha and ICC values were 0.97 and 0.98 for OHIP-49T and 0.90 and 0.93 for OHIP-14T. Mean scores of the OHIP-49T were significantly associated with prosthetic status (P = 0.0013) and prosthetic need (P = 0.0004), which were examined by dentists. The OHIP-14T score had stronger discriminatory ability than OHIP-14S.

The OHIP-49T showed satisfactory reliability and validity for this Taiwanese elderly population. The OHIP-14T is more effective to measure OHRQoL than OHIP-14S.”
“The present study

was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 SBI-0206965 years. We genotyped the adolescents’ GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, and AXL rs2304232 polymorphisms. Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype of GAS6 rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of AXL rs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes of AXL rs4802113. Boys with both the GG genotype of GAS6 rs8191973

and the GG genotype of GAS6 rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of the GAS6 rs8191973 and VX770 the A allele of the GAS6 rs8191974. In conclusion, GAS6 and AXL polymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys.”
“Nucleotide excision repair (NER) acts on a broad spectrum of large lesions, while base excision repair removes individual modified bases. Although both processes have been well studied in human cells, novel genes involved in these DNA repair pathways have been described. Using a heterologous complementation approach, we identified a fetal human cDNA that complemented two Escherichia coli mutants that are defective in 3-methyl adenine glycosylase and in three endonucleases, all of which are enzymes with important roles in base excision repair. The central cDNA open reading frame complemented NER mutant strains and promoted an increase in survival rate of bacteria exposed to UV light.

This study examined the role of antigen-presenting dendritic cells (DC) in restoration of host immunity. Circulating DC were isolated from peripheral blood of 23 patients with CHB before and 1, 3, and Selleckchem SRT2104 12 months after starting lamivudine therapy. The non-antigen-specific proliferation of DC was assessed in allogenic mixed leucocyte reaction. Dendritic cells were cultured with hepatitis B surface antigen (HBsAg) to prepare HBsAg-pulsed DC. Proliferative capacity and production of interleukin (IL)-12 and interferon (IFN)-gamma

of HBsAg-pulsed DC were evaluated. Circulating unpulsed DC and HBsAg-pulsed DC showed significantly higher levels of T-cell proliferation capacities 1 month after lamivudine therapy compared to proliferation levels before therapy (P < 0.05). HBsAg-pulsed DC also produced significantly higher levels of IL-12 and IFN-gamma with lamivudine therapy compared to levels before therapy (P < 0.05). HBsAg-pulsed DC from lamivudine-treated patients induced proliferation of T cells

of patients with CHB in an antigen-specific manner (P < 0.05). However, T-cell stimulatory capacity of DC did not increase significantly 3 and 12 months after lamivudine therapy YH25448 compared to 1 month after lamivudine therapy. Immune restoration as a result of lamivudine therapy is regulated at least in part by activation

of DC. However, progressive activation of DC was not seen as treatment duration FK228 datasheet progressed, indicating the limitations of this mechanism of viral clearance.”
“A rich thermal magnetic phase diagram has been determined by magneto-optical Kerr magnetometry and microscopy in a He+ ion irradiated ultrathin Pt/Co(0.5 nm)/Pt film. The components of the net magnetization and the evolution and disappearance of the ribbonlike magnetic domain pattern have been studied in the perpendicular to in-plane spin reorientation transition temperature region. As observed in a dipolar frustrated ferromagnet, the ribbon pattern blurs progressively with increasing the temperature as due to efficient spatial fluctuations. We emphasize the limitation of present theories for interpreting such a type of dynamic transition. (C) 2010 American Institute of Physics. [doi:10.1063/1.

The mean age for patients and controls was 8.2 +/- A 4.5 and 9.6 +/- A 4.2 years, respectively (p > 0.05). QTc dispersion significantly increased after anthracycline treatment (p = 0.02). TDI showed decreased SB273005 E’ velocity (p < 0.001) and E’/A’ ratio (p < 0.001) at lateral tricuspid annulus segment in TG-I, and these findings continued in TG-II and -III. In addition, S’ velocity decreased in TG-I, -II, and -III at lateral mitral annulus (10.5 +/- A 2.6 cm/s, p < 0.05; 9.9 +/- A 2.2 cm/s, p < 0.001; and 10.1 +/- A 2.3 cm/s, p < 0.01, respectively). However, decrease in left-ventricular

ejection fraction was statistically significant in TG-II and -III (p < 0.001). Although myocardial performance index was significantly increased in all treatment groups in both segments, it was primarily due to significant increases in isovolumic relaxation time at the lateral tricuspid annulus and isovolumic contraction time at the lateral mitral annulus. Abnormalities in diastolic function in right ventricle and systolic function in the left ventricle were observed even with a cumulative anthracycline dose < 120 mg/m(2) by TDI. In addition, anthracycline treatment led to an increase in QTc dispersion.”
“One new triterpenoid olean-18-ene-1 beta,

2 alpha, 3 beta-triol (1) along with four known compounds were isolated from the chloroform extract of the aerial part of Salvia atropatana Bunge. The known compounds selleck chemicals check details were two flavonoids, 5-hydroxy-7,4′-dimethoxyflavone (2) and 5-hydroxy-6,7,4′-trimethoxyflavone (3), an abietane-type diterpene namely taxodione (4) and a phytosterol namely gamma-sitosterol (5). The structure of (1) was elucidated by comprehensive spectroscopic analysis including electron ionization-mass spectra (EI-MS), H-1 NMR, C-13 NMR, distortionless enhancement by polarization transfer (DEPT), H, H correlation spectroscopy (COSY), heteronuclear

multiple quantum coherence (HMQC) and heteronuclear multiple bond correlation (HMBC). The structure of known compounds 2-5 were identified by comparison of their spectral data with those reported in the literature.”
“Statins (HMG-CoA reductase inhibitors) may decrease inflammation in postacute Kawasaki disease (KD) complicated by coronary artery aneurysm (CAA) and promote vascular remodeling. There are limited data on their safety in young children. Twenty patients with CAAs after KD (median CAA z-score = +25) were treated with 5/10 mg atorvastatin daily for a median of 2.5 years (range 0.5-6.8) starting at a median of 2.3 years (range 0.3-8.9) after acute KD (median age 9.3 years [range 0.7-14.3]). Compliance with treatment was excellent: only one patient reported minor side effects (joint pain, no change in medication). Average total cholesterol before atorvastatin was 3.73 +/- A 0.84 mmol/L and after atorvastatin was 3.21 +/- A 0.46 mmol/L (relative decrease -14 %, p = 0.02); low-density lipoprotein cholesterol was 1.99 +/- A 0.

05). Phosphatidylglycerophosphate synthase-1 single-nucleotide polymorphisms (rs4082919) showed the most significant triglyceride treatment interaction in the full cohort (P=0.0009).

Conclusions-This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects

of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.”
“Ovarian cancer is the deadliest gynecologic cancer. Unlike many cancers such as breast, cervical and colon cancers, there is no easily clinically identifiable pre-malignant phase of this malignancy making early identification difficult. Similarly, unlike lung, head Screening Library cost and neck, and skin cancers, there is not easily identifiable risk factor making prevention short of oophorectomy difficult. Even

so, theories as to the causative factors of ovarian cancer continue to evolve making our understanding of the genesis of ovarian cancer more clear. Genetics, parity, environment, hormonal factors, and inflammation all play an important and pivotal role in the development of ovarian cancer. The most current understanding of these elements and their respective contribution to the development of this cancer are presented in this chapter.”
“Czochralski- and float-zone-grown silicon detectors were irradiated with 2 to 5 MeV protons. Capacitance-voltage (CV) measurements served to deduce the effective doping profiles and current-voltage selleck chemicals llc (IV) measurements SBE-β-CD in vivo served to obtaining information

on irradiation-induced deep levels. The CV measurements show that the proton-induced net space charge is positive or negative depending on the energy of the bombarding ion. The commonly employed nonionizing energy loss hypothesis was tested with the low energy proton regime and prominent previously unobserved deviations from predictions were noted. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3371714]“
“Background

A barrier to statin therapy is myopathy associated with elevated systemic drug exposure. Our objective was to examine the association between clinical and pharmacogenetic variables and statin concentrations in patients.

Methods and Results

In total, 299 patients taking atorvastatin or rosuvastatin were prospectively recruited at an outpatient referral center. The contribution of clinical variables and transporter gene polymorphisms to statin concentration was assessed using multiple linear regression. We observed 45-fold variation in statin concentration among patients taking the same dose. After adjustment for sex, age, body mass index, ethnicity, dose, and time from last dose, SLCO1B1 c.521T>C (P<0.001) and ABCG2 c.

Phase composition analyses show that the La can substitute on the Ca sites completely, and have no influence on the phase composition. The impedance spectroscopy at room temperature indicates that the La doping can maintain the dielectric permittivity of CaCu3Ti4O12 (similar to 10(4)). The relationships between electrical current density versus applied electrical field show that these ceramic samples exhibit nonlinear varistor characteristics, which should be ascribed to the existing potential barrier height at the grain boundary.”
“In this work, we report the synthesis and characterization of poly(butyl monoitacotiate-co-acrylamide) hydrogels to be used as

drug release agents. Four isomers of butanol were used to synthesize the hydrogels. The influence of butyl monoitaconate isomery on swelling behavior, Young’s and compression Wnt inhibitor moduli, cross-linking density and molar mass between cross-links are reported. It was found that by increasing butyl ramification,

ML323 equilibrium degree of swelling, and the time for reaching swelling equilibrium decreases. Cross-linking density, Young’s and compression moduli increases as butyl ramification increases. The release of theophylline and aminophylline drugs used in therapy for respiratory diseases were studied and it was found that theophylline was released faster than aminophylline (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 112: 16301635, 2009″
“Objective-To determine accuracy, intermethod agreement, and inter-reviewer agreement for multisequence magnetic resonance imaging (MRI) and 2-view orthogonal myelography in small-breed dogs with first-time intervertebral disk (IVD) extrusion.

Design-Prospective evaluation study.

Animals-24 dogs with thoracolumbar IVD extrusion.

Procedures-Each dog underwent MRI and myelography. Images obtained with each modality were independently evaluated and assigned standardized scores in a blinded manner by 3 reviewers. Results were compared with surgical findings. Inter-reviewer and intermethod agreements were assessed via kappa statistics. Accuracy

was assessed as the percentage of dogs for which >= 2 of 3 reviewers recorded findings identical to those determined surgically.

Results-Inter-reviewer agreement was substantial for site (kappa = 0.70) and side of IVD extrusion (kappa = 0.62) in T2-weighted magnetic resonance images and was substantial MK-2206 in vivo for site (kappa = 0.72) and fair for side of extrusion (kappa = 0.37) in myelographic images. Agreement for site between each modality and surgical findings was near perfect (kappa = 0.94 and 0.88 for MRI and myelography, respectively). Intermethod agreement was substantial for site (kappa = 0.71) and moderate for side of extrusion (kappa = 0.40). Accuracy of MRI for site and side was 100% when results for T1-weighted, T2-weighted, and contrast-enhanced T1-weighted sequences were combined. Accuracy of myelography was 90.9% and 54.5% for site and side, respectively.