(C) 2012 Wiley Periodicals, Inc. Develop Neurobiol 72: 9901005, 2012″
“Liposarcomas (LS) are mesenchymal tumors that can recur after surgical resection and often do not respond to presently find more available medical therapies. This study demonstrates the dependence of LS on de novo long-chain fatty acid synthesis for growth. Lipogenesis can be impaired by inhibiting the activities of lipogenic enzymes. including acetyl CoA-carboxylase (ACC) and fatty acid synthase (FASN), or by suppressing the expression of key genes involved in the pathway and its regulation The FASN inhibitors cerulenin and orlistat reduced the growth of two
LS cell lines (LiSa2. SW872). as did inhibition of ACC with soraphen A CDDO-Me. a synthetic triterpenoid. suppressed expression of Spot 14 and FASN genes and likewise inhibited LS cell growth Importantly. the anti-proliferative effect of each agent was prevented by the co-administration of palmitate, the major product of cellular long-chain fatty acid synthesis. In stark contrast to LS cells, these compounds had no effect on the growth of fibroblasts
Four biochemically distinct agents that target critical CCI-779 points in the fatty acid synthetic pathway exert anti-proliferative effects on LS cells, and rescue of cell growth by palmitic acid suggests that reduced tumor cell lipogenesis mediates the growth inhibition These findings warrant further studies aimed at the clinical exploitation of the dependence of LS cell growth on fatty acids”
“A topological insulator is the state of quantum matter possessing
gapless spin-locking surface states across the bulk band gap, which has created new opportunities from novel electronics to energy conversion. However, the large concentration of bulk residual carriers has been a major challenge for revealing the property of the topological surface state by electron transport VS-6063 measurements. Here we report the surface-state-dominant transport in antimony-doped, zinc oxide-encapsulated Bi2Se3 nanoribbons with suppressed bulk electron concentration. In the nanoribbon with sub-10-nm thickness protected by a zinc oxide layer, we position the Fermi levels of the top and bottom surfaces near the Dirac point by electrostatic gating, achieving extremely low two-dimensional carrier concentration of 2×10(11) cm(-2). The zinc oxide-capped, antimony-doped Bi2Se3 nanostructures provide an attractive materials platform to study fundamental physics in topological insulators, as well as future applications.”
“The nuclear arsenal and the use of nuclear technologies have enhanced the likelihood of whole-body/partial-body radiation exposure. The central nervous system is highly susceptible to even low doses of radiation.